Evidence map›Paper›PMID 33746778›Full record

ArticleFrontiers in physiology2021

Intra-Arterial, but Not Intrathecal, Baclofen and Codeine Attenuates Cough in the Cat.

Wendy L Olsen, Melanie Rose, Frank J Golder, Cheng Wang, Julie C Hammond, Donald C Bolser

Open access · goldAbstract read
In one paragraph

Article in Frontiers in physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Peripheral antitussives affect temporal features of tracheobronchial coughing in cats.Journal of applied physiology (Bethesda, Md. : 1985) · 2025
    Article
  2. Cough hypersensitivity and chronic cough.Nature reviews. Disease primers · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Wendy L OlsenDepartment of Physiological Sciences, University of Florida, Gainesville, FL, United States.
Melanie RoseDepartment of Physiological Sciences, University of Florida, Gainesville, FL, United States.
Frank J GolderDepartment of Physiological Sciences, University of Florida, Gainesville, FL, United States.
Cheng WangDepartment of Physiological Sciences, University of Florida, Gainesville, FL, United States.
Julie C HammondDepartment of Physiological Sciences, University of Florida, Gainesville, FL, United States.
Donald C BolserDepartment of Physiological Sciences, University of Florida, Gainesville, FL, United States.
University of Florida · US

Funding

Breathing Research and Therapeutics (BREATHE)T32HL134621 · NHLBI · UNIVERSITY OF FLORIDA · PI Gordon S. Mitchell · 2017 to 2026
$3.4M
Influence of Opioids on the Brainstem Respiratory NetworkR01HL155721 · NHLBI · UNIVERSITY OF FLORIDA · PI BOLSER, DONALD C, MORRIS, KENDALL FRANCIS · 2021 to 2024
$2.7M
Central Mechanisms of Airway ProtectionR01HL103415 · NHLBI · UNIVERSITY OF FLORIDA · PI BOLSER, DONALD C, DAVENPORT, PAUL W · 2010 to 2013
$2.2M
NHLBI NIH HHS R01 HL103415NHLBI NIH HHS R01 HL155721NHLBI NIH HHS T32 HL134621
6 · The paper itself

Abstract

Centrally-acting antitussive drugs are thought to act solely in the brainstem. However, the role of the spinal cord in the mechanism of action of these drugs is unknown. The purpose of this study was to determine if antitussive drugs act in the spinal cord to reduce the magnitude of tracheobronchial (TB) cough-related expiratory activity. Experiments were conducted in anesthetized, spontaneously breathing cats (

Indexed as

airway protectionantitussivesbaclofencodeinecoughGABA-B receptor agonistintrathecalopioid

Identifiers

PMID33746778
PMCPMC7973226
OpenAlexW3134564309

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.