ReviewFrontiers in physiology2021
Pb Toxicity on Gut Physiology and Microbiota.
Review in Frontiers in physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 77 citations in OpenAlex.
- Major heavy metals and human gut microbiota composition: a systematic review with nutritional approach.Journal of health, population, and nutrition · 2025Pooled it
- Amelioration of intestinal barrier function and reduction of blood lead level in adult women with recurrent spontaneous abortion by a novel product of dietary fiber mixture, Holofood.Journal of health, population, and nutrition · 2023Trial
- Fucoidan Attenuates Lead-Induced Liver Injury Associated with IGFBP1 and Gut Microbiota-Derived Tryptophol Metabolism.Marine drugs · 2026Article
- Probiotic and Microbial Enzymatic Mechanisms for PFAS Detoxification.Probiotics and antimicrobial proteins · 2026Review
- Lactobacillus protects against lead-induced hepatotoxicity by preserving the gut barrier and microbiota remodeling.BMC microbiology · 2026Article
- Role of gut microbiota in lead-induced neural damage in diabetic mice.World journal of diabetes · 2026Article
- Environmental pollutants and the gut microbiota: mechanistic links from exposure to systemic disease.Frontiers in microbiology · 2026Review
- Nutritional Modulation of the Gut Microbiome in Relation to Prenatal Lead-Induced Neurotoxicity: A Review.Nutrients · 2025Review
- Metal-induced changes in the early-life gut microbial composition and life-history traits in three insectivorous passerines.Environmental science and pollution research international · 2025Article
- Investigating zinc's role in mitigating blood lead levels' toxicity on gut microbiota diversity: NHANES 2007-2010.Toxicology letters · 2025Article
- Evaluation of Heavy Metal Concentration in Different Organs of Labeo rohita in Water and Sediment of Marala Ravi Link Canal (MRL) and Upper Chenab Canal (UCC) of Chenab River, Pakistan, and Their Health Implications.Biological trace element research · 2025Article
- The role of the gut microbiome in the associations between lead exposure and child neurodevelopment.Toxicology letters · 2025Review
- Dietary Fiber Intake Improves Osteoporosis Caused by Chronic Lead Exposure by Restoring the Gut-Bone Axis.Nutrients · 2025Article
- Heavy Metal Concentrations in Water, Sediment, and Fish Species in Chashma Barrage, Indus River: A Comprehensive Health Risk Assessment.Biological trace element research · 2025Article
- Human health and ecological risk assessment of heavy metals in topsoil of different peatland use types.Heliyon · 2024Article
- [Lead exposure aggravates AβNan fang yi ke da xue xue bao = Journal of Southern Medical University · 2023Article
- Interaction of Heavy Metal Lead with Gut Microbiota: Implications for Autism Spectrum Disorder.Biomolecules · 2023Review
- The ionome and proteome landscape of aging in laying hens and relation to egg white quality.Science China. Life sciences · 2023Article
- A rare case report of lead encephalopathy due to high blood lead level.Clinical case reports · 2023Article
- Lead exposure exacerbates adverse effects of HFD on metabolic function via disruption of gut microbiome, leading to compromised barrier function and inflammation.European journal of nutrition · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lead (Pb) is a toxic heavy metal, having profound threats to the global population. Multiple organs such as kidney, and liver, as well as nervous, hematologic, and reproductive systems, are commonly considered the targets of Pb toxicity. Increasing researches reported that the effects of Pb on gastrointestinal tracts are equally intensive, especially on intestinal microbiota. This review summarized Pb toxicity on gut physiology and microbiota in different animal models and in humans, of which the alterations may further have effects on other organs in host. To be more specific, Pb can impair gut barrier and increase gut permeability, which make inflammatory cytokines, immunologic factors, as well as microbial metabolites such as bile acids (BA) and short-chain fatty acids (SCFAs) enter the enterohepatic circulation easily, and finally induce multiple systematic lesion. In addition, we emphasized that probiotic treatment may be one of the feasible and effective strategies for preventing Pb toxicity.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.