Evidence map›Paper›PMID 33746708›Full record

ArticleFrontiers in neuroscience2021

The Impacts of Age and Sex in a Mouse Model of Childhood Narcolepsy.

Alissa A Coffey, Adam A Joyal, Akihiro Yamanaka, Thomas E Scammell

Open access · goldAbstract read
In one paragraph

Article in Frontiers in neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.8field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Alissa A CoffeyDepartment of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, United States.
Adam A JoyalDepartment of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, United States.
Akihiro YamanakaDepartment of Neuroscience II, Research Institute of Environmental Medicine, Nagoya University, Nagoya, Japan.
Thomas E ScammellDepartment of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, United States.
Harvard University · USBeth Israel Deaconess Medical Center · USNagoya University · JP

Funding

TRAINING IN SLEEP, CIRCADIAN &RESPIRATORY NEUROBIOLOGYT32HL007901 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI Charles A Czeisler · 1998 to 2026
$18.5M
Mechanisms of CataplexyR01NS106032 · NINDS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI SCAMMELL, THOMAS E · 2018 to 2021
$1.6M
Early-onset narcolepsy: A role for histamineF32HD101193 · NICHD · BETH ISRAEL DEACONESS MEDICAL CENTER · PI COFFEY, ALISSA A · 2019 to 2021
$84k
NHLBI NIH HHS T32 HL007901NICHD NIH HHS F32 HD101193NINDS NIH HHS R01 NS106032
6 · The paper itself

Abstract

Narcolepsy is a sleep disorder caused by selective death of the orexin neurons that often begins in childhood. Orexin neuron loss disinhibits REM sleep during the active period and produces cataplexy, episodes of paralysis during wakefulness. Cataplexy is often worse when narcolepsy develops in children compared to adults, but the reason for this difference remains unknown. We used

Indexed as

agecataplexychildhoodmicenarcolepsyorexinpediatricsex

Identifiers

PMID33746708
PMCPMC7969886
OpenAlexW3133775181

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.