Evidence map›Paper›PMID 33746596›Full record

SynthesisInternational journal of medical sciences2021

Efficacy and Safety of CAR-T Therapy for Relapse or Refractory Multiple Myeloma: A systematic review and meta-analysis.

Qin Yang, Xin Li, Fangrong Zhang, Qiaohui Yang, Wen Zhou, Jing Liu

Registry-linked trialAbstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in International journal of medical sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06282978 (An Open Label, Multicenter, Phase II Study of Elranatamab as Single Agent for the Treatment of Relapsed or Refractory Myeloma in Patients Previously Exposed to Three-drug Classes), which is not on this map. Cited by 22 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06282978 phase2active not recruitingnot on this mapstarted 2023, after this paper: background citation

An Open Label, Multicenter, Phase II Study of Elranatamab as Single Agent for the Treatment of Relapsed or Refractory Myeloma in Patients Previously Exposed to Three-drug Classes (GEM-RANTAB)

TypeinterventionalSponsorPETHEMA FoundationRan2023 to 2029Enrolled50ConditionsMultiple Myeloma in RelapseArmsElranatamab (PF-06863135)
3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Trial
  7. Article
  8. Review
  9. Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Immunotherapy of Multiple Myeloma: Current Status as Prologue to the Future.International journal of molecular sciences · 2023
    Review
  16. Article
  17. [Latest Findings on the Mechanism of the Interaction Between Multiple Myeloma Cells and Bone Marrow Microenvironment].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2023
    Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Qin YangDepartment of Hematology, The Third Xiangya Hospital, Central South University, Changsha, Hunan, P.R. China.
Xin LiDepartment of Hematology, The Third Xiangya Hospital, Central South University, Changsha, Hunan, P.R. China.
Fangrong ZhangDepartment of Hematology, The Third Xiangya Hospital, Central South University, Changsha, Hunan, P.R. China.
Qiaohui YangInstitute of Reproductive and Stem Cell Engineering, School of Basic Medical Science, Central South University, Changsha, Hunan, P.R. China.
Wen ZhouKey Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education; Key Laboratory of Carcinogenesis, National Health and Family Planning Commission, Cancer Research Institute, School of Basic Medical Science, Central South University, Changsha, Hunan, P.R. China.
Jing LiuDepartment of Hematology, The Third Xiangya Hospital, Central South University, Changsha, Hunan, P.R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

B-Cell Maturation AntigenClinical Trials as TopicDrug Resistance, NeoplasmFollow-Up StudiesHumansImmunotherapy, AdoptiveMultiple MyelomaNeoplasm Recurrence, LocalProgression-Free SurvivalReceptors, Chimeric AntigenB-Cell Maturation AntigenReceptors, Chimeric AntigenTNFRSF17 protein, humanantigensBCMACARsCAR-T therapyco-stimulatory domainmeta-analysisRRMMsystematic review

Identifiers

PMID33746596
PMCPMC7976586

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.