SynthesisInternational journal of medical sciences2021
Hemolysis in patients with Extracorporeal Membrane Oxygenation therapy for severe Acute Respiratory Distress Syndrome - a systematic review of the literature.
Synthesis in International journal of medical sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 54 citations in OpenAlex.
- Challenges and opportunities in ECMO monitoring: A mixed-methods appraisal.The journal of extra-corporeal technology · 2026Review
- Haemolytic injury and cardiovascular disease.Nature reviews. Cardiology · 2026Review
- From Early Models to Emerging Trends: The Evolution of Computational Hemolysis Prediction.Annals of biomedical engineering · 2026Review
- Iron Compartmentalisation and Vascular Endothelial Cell Dysfunction.Antioxidants (Basel, Switzerland) · 2026Review
- Extracorporeal Carbon Dioxide Removal in Acute Respiratory Distress Syndrome: Physiologic Rationale and Phenotype-Based Perspectives.Medicina (Kaunas, Lithuania) · 2026Review
- Algorithm for Reporting Free Hemoglobin in ECMO Patients: Need for a Multidisciplinary Approach.Journal of clinical medicine · 2026Article
- Hemolysis Monitoring Practices during Extracorporeal Membrane Oxygenation: A Survey Report.Blood purification · 2026Article
- The Impact of Venovenous Extracorporeal Membrane Oxygenation Cannulation Configuration on Hemodynamic Characteristics and Risks of Hemolysis.Annals of biomedical engineering · 2025Article
- Sex-specific glomerular filtration rate changes in response to acute hemoglobin exposure.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2025Article
- Material-Induced Platelet Adhesion/Activation and Hemolysis of Membrane Lung Components from Extracorporeal Membrane Oxygenation.Biomedicines · 2025Article
- Hemolysis, hemolytic markers, and mortality in sepsis: a scoping review.Intensive care medicine experimental · 2025Review
- What Are the Best Biocompatible Materials for Extracorporeal Membrane Oxygenation.Journal of functional biomaterials · 2025Review
- Hemolysis and Its Clinical Implications in Septic Patients with Acute Respiratory Failure.Journal of clinical medicine · 2025Article
- Performance Comparison of Centered and Tilted Blunt and Lighthouse Tip Cannulae for Drainage in Extracorporeal Life Support.Cardiovascular engineering and technology · 2025Article
- Total bilirubin as a marker for hemolysis and outcome in patients with severe ARDS treated with veno-venous ECMO.BMC anesthesiology · 2025Article
- Extracorporeal Membrane Oxygenation Use in Fat Embolism Syndrome: Current Perspectives and Clinical Insights (A 20-Year Review).Journal of clinical medicine · 2025Review
- Anticoagulation in venovenous extracorporeal membrane oxygenation.Frontiers in medicine · 2025Review
- Predictive Potential of ECMO Blood Flow for Hemolysis and Outcome of Patients with Severe ARDS.Journal of clinical medicine · 2024Article
- Mitigating hemoglobin-induced nephropathy: ApoHb-hp protection of podocytes.Physiological reports · 2024Article
- Blood trauma in veno-venous extracorporeal membrane oxygenation: low pump pressures and low circuit resistance matter.Critical care (London, England) · 2024Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Acute Respiratory Distress Syndrome (ARDS) is common in patients on the Intensive Care Unit and associated with significant mortality rates. In situations of severe respiratory insufficiency and failure of all possible conservative therapeutic approaches, veno-venous extracorporeal membrane oxygenation (VV ECMO) is used as a final option for temporary replacement of pulmonary function. ARDS as well as sepsis and VV ECMO treatment are all associated with intravascular hemolysis. The extent and relevance of intravascular hemolysis in the context of ARDS therapy is unclear. This systematic review aims to summarize the current evidence on the incidence and associated complications of intravascular hemolysis in adult patients with ARDS and treatment with VV ECMO. The databases MEDLINE, EMBASE and Web of Science were systematically searched and 19 publications fulfilled inclusion criteria. The incidence of hemolysis in patients with ARDS and treatment with VV ECMO ranged from 0 to 41% with survivors showing lower incidences and less severe hemolysis. A pump head thrombosis and high blood flows (≥3 l/min) as well as use of dual-lumen cannulas but not different pump models were associated with increased hemolysis. In conclusion, intravascular hemolysis in patients with ARDS and treatment with VV ECMO is a common and relevant complication that appears associated with increased mortality. Apart from ECMO hardware-settings, no additional possible causes for increased red cell breakdown such as disease severity, duration of ECMO therapy, or number and quality of red blood cell transfusions were investigated. Further research is needed to determine the origin and relevance of intravascular hemolysis in patients with ARDS and treatment with VV ECMO.
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