Evidence map›Paper›PMID 33746579›Full record

ArticleInternational journal of medical sciences2021

Co-culture with Endothelial Progenitor Cells promotes the Osteogenesis of Bone Mesenchymal Stem Cells via the VEGF-YAP axis in high-glucose environments.

Peilian Wu, Xia Zhang, Yun Hu, Dongrong Liu, Jinlin Song, Wenjie Xu, Hao Tan, Rui Lu, Leilei Zheng

Erratum issuedAbstract read
In one paragraph

Article in International journal of medical sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Peilian WuThe Affiliated Stomatology Hospital, Chongqing Medical University, Chongqing, 401147, China.
Xia ZhangThe Affiliated Stomatology Hospital, Chongqing Medical University, Chongqing, 401147, China.
Yun HuThe Affiliated Stomatology Hospital, Chongqing Medical University, Chongqing, 401147, China.
Dongrong LiuThe Affiliated Stomatology Hospital, Chongqing Medical University, Chongqing, 401147, China.
Jinlin SongThe Affiliated Stomatology Hospital, Chongqing Medical University, Chongqing, 401147, China.
Wenjie XuThe Affiliated Stomatology Hospital, Chongqing Medical University, Chongqing, 401147, China.
Hao TanThe Affiliated Stomatology Hospital, Chongqing Medical University, Chongqing, 401147, China.
Rui LuThe Affiliated Stomatology Hospital, Chongqing Medical University, Chongqing, 401147, China.
Leilei ZhengThe Affiliated Stomatology Hospital, Chongqing Medical University, Chongqing, 401147, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Patients with type 2 diabetes mellitus (T2DM) have a high risk of fracture and experience poor bone healing. In recent years, bone mesenchymal stem cells (BMSCs) and endothelial progenitor cells (EPCs) have become the most commonly used cells in cell therapy and tissue engineering. In this study, we found that high glucose levels had a negative effect on the differentiation of BMSCs and EPCs. Considering that EPCs-BMSCs sheets can provide endothelial cells and osteoblastic cells, we transplanted cell sheets into T2DM rats with bilateral skull defects. The outcomes of the

Indexed as

AnimalsBone Diseases, MetabolicBone MarrowCells, CulturedCoculture TechniquesCulture MediaDiabetes ComplicationsDiabetes Mellitus, ExperimentalDiabetes Mellitus, Type 2Endothelial Progenitor CellsGlucoseHumansIntracellular Signaling Peptides and ProteinsMaleMesenchymal Stem CellsOsteogenesisCulture MediaGlucoseIntracellular Signaling Peptides and ProteinsStreptozocinVascular Endothelial Growth Factor Avascular endothelial growth factor A, ratYap1 protein, ratYAP-Signaling ProteinsBMSCsEPCsHigh glucosetype 2 diabetes mellitusVEGFYAP

Identifiers

PMID33746579
PMCPMC7976568

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.