Evidence map›Paper›PMID 33746477›Full record

ArticleJournal of microelectromechanical systems : a joint IEEE and ASME publication on microstructures, microactuators, microsensors, and microsystems2020

A 512-Channel Multi-Layer Polymer-Based Neural Probe Array.

Kee Scholten, Christopher E Larson, Huijing Xu, Dong Song, Ellis Meng

Open access · greenAbstract read
In one paragraph

Article in Journal of microelectromechanical systems : a joint IEEE and ASME publication on microstructures, microactuators, microsensors, and microsystems, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 33 citations in OpenAlex.

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  6. Characterization of thin film Parylene C device curvature and the formation of helices via thermoforming.Journal of micromechanics and microengineering : structures, devices, and systems · 2023
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  13. The Future of Neuroscience: Flexible and Wireless Implantable Neural Electronics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021
    Review
  14. Article
  15. Fabrication of a Multilayer Implantable Cortical Microelectrode Probe to Improve Recording Potential.Journal of microelectromechanical systems : a joint IEEE and ASME publication on microstructures, microactuators, microsensors, and microsystems · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Kee ScholtenDepartment of Biomedical Engineering, Viterbi School of Engineering, University of Southern California, Los Angeles, CA 90089 USA.
Christopher E LarsonDepartment of Biomedical Engineering, Viterbi School of Engineering, University of Southern California, Los Angeles, CA 90089 USA.
Huijing XuDepartment of Biomedical Engineering, Viterbi School of Engineering, University of Southern California, Los Angeles, CA 90089 USA.
Dong SongDepartment of Biomedical Engineering, Viterbi School of Engineering, University of Southern California, Los Angeles, CA 90089 USA.
Ellis MengDepartment of Biomedical Engineering, Viterbi School of Engineering, University of Southern California, Los Angeles, CA 90089 USA.
University of Southern California · US

Funding

Flexible neural probe arrays for large-scale cortical and subcortical recordingU01NS099703 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MENG, ELLIS · 2016 to 2018
$1.2M
NINDS NIH HHS U01 NS099703
6 · The paper itself

Abstract

We present for the first time the design, fabrication, and preliminary bench-top characterization of a high-density, polymer-based penetrating microelectrode array, developed for chronic, large-scale recording in the cortices and hippocampi of behaving rats. We present two architectures for these targeted brain regions, both featuring 512 Pt recording electrodes patterned front-and-back on micromachined eight-shank arrays of thin-film Parylene C. These devices represent an order of magnitude improvement in both number and density of recording electrodes compared with prior work on polymer-based microelectrode arrays. We present enabling advances in polymer micro-machining related to lithographic resolution and a new method for back-side patterning of electrodes.

Indexed as

bioMEMSbrain machine interfacesMicroelectrode arrayneural probeParylene

Identifiers

PMID33746477
PMCPMC7978043
OpenAlexW3035362106

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.