Evidence map›Paper›PMID 33746400›Full record

ArticleJournal of parasitic diseases : official organ of the Indian Society for Parasitology2021

Serum levels of CC chemokine ligands in cutaneous leishmaniasis patients.

Gholamhossein Hassanshahi, Seyed Ebrahim Alavi, Hossein Khorramdelazad, Zahra Ahmadi, Ali Fattahi Bafghi, Seyed Hossein Abdollahi, Hasan Ebrahimi Shahmabadi

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of parasitic diseases : official organ of the Indian Society for Parasitology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 82% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Gholamhossein HassanshahiMolecular Medicine Research Center, Rafsanjan University of Medical Sciences, P.O. Box 771751-735, Rafsanjan, Iran.
Seyed Ebrahim AlaviSchool of Pharmacy, The University of Queensland, Woolloongabba, 4102 Australia.
Hossein KhorramdelazadMolecular Medicine Research Center, Rafsanjan University of Medical Sciences, P.O. Box 771751-735, Rafsanjan, Iran.
Zahra AhmadiMolecular Medicine Research Center, Rafsanjan University of Medical Sciences, P.O. Box 771751-735, Rafsanjan, Iran.
Ali Fattahi BafghiMedical Parasitology and Mycology Department, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Seyed Hossein AbdollahiMolecular Medicine Research Center, Rafsanjan University of Medical Sciences, P.O. Box 771751-735, Rafsanjan, Iran.
Hasan Ebrahimi ShahmabadiDepartment of Microbiology, Faculty of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.ORCID 0000-0001-5222-3829
Rafsanjan University of Medical Sciences · IRShahid Sadoughi University of Medical Sciences and Health Services · IRThe University of Queensland · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The crucial functions of chemokine/receptors in numerous parasitic infections, including leishmaniasis, are well documented. This study aimed to assess the serum levels of CC ligand (CCL) 2, CCL5, and CCL11 in cutaneous leishmaniasis (CL) patients. 64 patients, suffering from CL and 100 healthy people were selected, and their blood serum concentrations of CCL2, CCL5, and CCL11 were measured using enzyme-linked immunosorbent assay. The results demonstrated that while the mean serum levels of CCL5 and CCL11 increased significantly in CL patients, the mean serum levels of CCL2 decreased, compared to the control group. Despite the sufficient production of CCL5 and CCL11 in CL patients, they suffered from CCL2 deficiency, as the defense mechanism against parasitic infection. These findings suggest a mechanism that might partially explain the patients' susceptibility to persistent infection and their inability to clear the parasites.

Indexed as

CC ligandChemokinesLeishmaniasisParasitic infection

Identifiers

PMID33746400
PMCPMC7921228
OpenAlexW3093550233

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.