Evidence map›Paper›PMID 33746158›Full record

ArticleJournal of atherosclerosis and thrombosis2022

Clinical Importance of the LDL-C/Apolipoprotein B Ratio for Neointimal Formation after Everolimus-Eluting Stent Implantations.

Naotaka Akutsu, Koichiro Hori, Saki Mizobuchi, Akihito Ogaku, Yutaka Koyama, Hidesato Fujito, Riku Arai, Yasunari Ebuchi, Suguru Migita, Tomoyuki Morikawa and 7 more

Open access · diamondAbstract read
In one paragraph

Article in Journal of atherosclerosis and thrombosis, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 21 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 1 institution in 1 country.

Naotaka AkutsuDivision of Cardiology, Department of Medicine, Nihon University School of Medicine.
Koichiro HoriDivision of Cardiology, Department of Medicine, Nihon University School of Medicine.
Saki MizobuchiDivision of Cardiology, Department of Medicine, Nihon University School of Medicine.
Akihito OgakuDivision of Cardiology, Department of Medicine, Nihon University School of Medicine.
Yutaka KoyamaDivision of Cardiology, Department of Medicine, Nihon University School of Medicine.
Hidesato FujitoDivision of Cardiology, Department of Medicine, Nihon University School of Medicine.
Riku AraiDivision of Cardiology, Department of Medicine, Nihon University School of Medicine.
Yasunari EbuchiDivision of Cardiology, Department of Medicine, Nihon University School of Medicine.
Suguru MigitaDivision of Cardiology, Department of Medicine, Nihon University School of Medicine.
Tomoyuki MorikawaDivision of Cardiology, Department of Medicine, Nihon University School of Medicine.
Takehiro TamakiDivision of Cardiology, Department of Medicine, Nihon University School of Medicine.
Keisuke KojimaDivision of Cardiology, Department of Medicine, Nihon University School of Medicine.
Nobuhiro MurataDivision of Cardiology, Department of Medicine, Nihon University School of Medicine.
Toshihiko NishidaDivision of Cardiology, Department of Medicine, Nihon University School of Medicine.
Daisuke KitanoDivision of Cardiology, Department of Medicine, Nihon University School of Medicine.
Daisuke FukamachiDivision of Cardiology, Department of Medicine, Nihon University School of Medicine.
Yasuo OkumuraDivision of Cardiology, Department of Medicine, Nihon University School of Medicine.
Nihon University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsSmaller low-density lipoprotein (LDL) particle size has been suggested to result in the development of endothelial dysfunction, atherosclerosis, and in-stent restenosis (ISR); however, little is known regarding the impact of the LDL particle size on the neointima formation leading to ISR after everolimus-eluting stent (EES) implantation.

methodsIn this study, we have included 100 patients to examine the relationship between an LDL-C/apolipoprotein B (Apo B) ≤ 1.2, reportedly representing the LDL particle size, and the neointimal characteristics using optical coherence tomography (OCT) and coronary angioscopy (CAS) during the follow-up coronary angiography (CAG) period (8.8±2.5 months) after EES implantation. We divided them into two groups: LDL-C/Apo B ≤ 1.2 group (low LDL-C/Apo B group, n=53) and LDL-C/Apo B >1.2 group (high LDL-C/Apo B group, n=47).

resultsThe low LDL-C/Apo B group had a significantly larger neointimal volume (12.8±5.3 vs. 10.3±4.9 mm

conclusionsA low LDL-C/Apo B ratio was found to be strongly associated with neointimal proliferation and neointimal instability evidenced chronically by OCT and CAS. An LDL-C/Apo B ≤ 1.2 will be of aid in terms of identifying high-risk patients after EES implantation.

Indexed as

Coronary Artery DiseaseDrug-Eluting StentsPercutaneous Coronary InterventionApolipoproteinsApolipoproteins BCholesterol, LDLCoronary AngiographyCoronary VesselsEverolimusHumansNeointimaTomography, Optical CoherenceApolipoproteinsApolipoproteins BCholesterol, LDLEverolimusCoronary angioscopyEverolimus-eluting stentLow-Density Lipoprotein Cholesterol (LDL-C)/apolipoprotein B ratioNeointimal gradeNeointimal volumeOptical coherence tomographyYellow grade

Identifiers

PMID33746158
PMCPMC9090476
OpenAlexW3137840314

What OpenQuestion holds

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LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.