Evidence map›Paper›PMID 33746070›Full record

ArticleMetabolic engineering2021

Tailored biosynthesis of gibberellin plant hormones in yeast.

Kanchana R Kildegaard, Jonathan A Arnesen, Belén Adiego-Pérez, Daniela Rago, Mette Kristensen, Andreas K Klitgaard, Esben H Hansen, Jørgen Hansen, Irina Borodina

Open access · hybridAbstract read
In one paragraph

Article in Metabolic engineering, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 64 citations in OpenAlex.

  1. Review
  2. Metabolic Engineering for Gibberellic Acid Production inMolecules (Basel, Switzerland) · 2026
    Review
  3. Article
  4. Review
  5. Optimized GAACS omega · 2025
    Article
  6. Optimizing longifolene production inSynthetic and systems biotechnology · 2025
    Article
  7. Review
  8. Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Engineering ofMetabolic engineering communications · 2022
    Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 2 countries.

Kanchana R KildegaardThe Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kemitorvet 220, 2800, Kgs. Lyngby, Denmark.
Jonathan A ArnesenThe Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kemitorvet 220, 2800, Kgs. Lyngby, Denmark.
Belén Adiego-PérezThe Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kemitorvet 220, 2800, Kgs. Lyngby, Denmark.
Daniela RagoThe Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kemitorvet 220, 2800, Kgs. Lyngby, Denmark.
Mette KristensenThe Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kemitorvet 220, 2800, Kgs. Lyngby, Denmark.
Andreas K KlitgaardThe Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kemitorvet 220, 2800, Kgs. Lyngby, Denmark.
Esben H HansenRiver Stone Biotech ApS, Fruebjergvej 3, 2100, København Ø, Denmark.
Jørgen HansenRiver Stone Biotech ApS, Fruebjergvej 3, 2100, København Ø, Denmark.
Irina BorodinaThe Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kemitorvet 220, 2800, Kgs. Lyngby, Denmark. Electronic address: irbo@biosustain.dtu.dk.
Novo Nordisk Foundation · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The application of small amounts of natural plant growth hormones, such as gibberellins (GAs), can increase the productivity and quality of many vegetable and fruit crops. However, gibberellin growth hormones usage is limited by the high cost of their production, which is currently based on fermentation of a natural fungal producer Fusarium fujikuroi that produces a mix of several GAs. We explored the potential of the oleaginous yeast Yarrowia lipolytica to produce specific profiles of GAs. Firstly, the production of the GA-precursor ent-kaurenoic acid (KA) at 3.75 mg/L was achieved by expression of biosynthetic enzymes from the plant Arabidopsis thaliana and upregulation of the mevalonate (MVA) pathway. We then built a GA

Indexed as

FusariumGibberellinsBiosynthetic PathwaysPlant Growth RegulatorsGibberellinsPlant Growth RegulatorsGibberellinsIsoprenoidsOleaginous yeastPlant growth hormonesYarrowia lipolytica

Identifiers

PMID33746070
PMCPMC8205117
OpenAlexW3137117380

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.