Evidence map›Paper›PMID 33745492›Full record

ArticleJournal of the International Neuropsychological Society : JINS2022

Prognostic Value of Learning and Retention Measures from the Free and Cued Selective Reminding Test to Identify Incident Mild Cognitive Impairment.

Ellen Grober, Cuiling Wang, Melissa Kitner-Triolo, Richard B Lipton, Claudia Kawas, Susan M Resnick

Abstract read
In one paragraph

Article in Journal of the International Neuropsychological Society : JINS, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Trial
  2. Article
  3. Review
  4. Article
  5. Article
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  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ellen GroberDepartment of Neurology, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, Bronx, NY, USA.ORCID 0000-0001-7998-5778
Cuiling WangDepartment of Neurology, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, Bronx, NY, USA.
Melissa Kitner-TrioloLaboratory of Behavioral Neuroscience, National Institute on Aging, Baltimore, MD, USA.
Richard B LiptonDepartment of Neurology, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, Bronx, NY, USA.
Claudia KawasDepartment of Neurology, University of California, Irvine, CA, USA.
Susan M ResnickLaboratory of Behavioral Neuroscience, National Institute on Aging, Baltimore, MD, USA.

Funding

Vascular Structure and Function in Cognitive AgingP01AG003949 · NIA · YESHIVA UNIVERSITY · PI STEVEN SUEY-MING CHIN · 1985 to 2026
$73.9M
Research Education ComponentP30AG066507 · NIA · JOHNS HOPKINS UNIVERSITY · PI Corinne Pettigrew · 2020 to 2026
$29.3M
Early Markers of Alzheimer DiseaseZIAAG000185 · NIA · NATIONAL INSTITUTE ON AGING · PI WALKER, KEENAN · 2009 to 2025
$20.4M
MRI Measures of Cerebrovascular Injury and AD Atrophy in a Study of LatinosRF1AG054548 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI DECARLI, CHARLES, GONZALEZ, HECTOR M · 2017 to 2017
$14.7M
The biological underpinnings of Motoric Cognitive Risk syndrome: a multi-center studyR01AG057548 · NIA · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI VERGHESE, JOE · 2020 to 2024
$8.0M
A global epidemiology of cognitive impairment and dementia due to Alzheimer's disease and related disorders: the COSMIC CollaborationR01AG057531 · NIA · UNIVERSITY OF NEW SOUTH WALES · PI Perminder S SACHDEV · 2023 to 2026
$5.9M
Study of Latinos-Investigation of Neurocognitive Aging (SOL-INCA)R01AG048642 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GONZALEZ, HECTOR M · 2015 to 2019
$5.7M
COSMIC: An international consortium to identify risk and protective factors and biomarkers of cognitive ageing and dementia in diverse ethno-racial groups and geographical settingsRF1AG057531 · NIA · UNIVERSITY OF NEW SOUTH WALES · PI SACHDEV, PERMINDER S · 2017 to 2020
$2.9M
The role of personality in cognitive aging and dementiaR01AG060933 · NIA · STATE UNIVERSITY NEW YORK STONY BROOK · PI SCOTT, STACEY BETH · 2019 to 2023
$2.4M
Einstein Center for Excellence for Clinical Trials in NeuroscienceU10NS077308 · NINDS · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI LIPTON, RICHARD B., SHINNAR, SHLOMO · 2011 to 2017
$2.2M
The biological underpinnings of Motoric Cognitive Risk syndrome: a multi-center studyR56AG057548 · NIA · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI VERGHESE, JOE · 2017 to 2017
$1.2M
The Misdiagnosis of Cerebrovascular Disease in Emergent Headache EvaluationsK23NS107643 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI LIBERMAN, AVA L · 2018 to 2022
$997k
NIA NIH HHS K23 AG049466NIA NIH HHS P01 AG003949NIA NIH HHS P30 AG066507NIA NIH HHS R01 AG048642NIA NIH HHS R01 AG057531NIA NIH HHS R01 AG057548NIA NIH HHS R01 AG060933NIA NIH HHS R21 AG056920NIA NIH HHS R56 AG057548NIA NIH HHS RF1 AG054548NIA NIH HHS RF1 AG057531NINDS NIH HHS K23 NS107643NINDS NIH HHS U10 NS077308
6 · The paper itself

Abstract

objectiveTo compare the predictive validity of learning and retention measures from the picture version of the Free and Cued Selective Reminding Test with Immediate Recall (pFCSRT + IR) for identifying incident mild cognitive impairment (MCI).

methodsLearning was defined by the sum of free recall (FR) and retention by delayed free recall (DFR) tested 15-20 min later. Totally, 1422 Baltimore Longitudinal Study of Aging (BLSA) participants (mean age 69.6 years, 54% male, mean 16.7 years of education) without dementia or MCI received the pFCSRT + IR at baseline and were followed longitudinally. Cox proportional hazards models were used to evaluate the effect of baseline learning and retention on risk of MCI.

resultsIn total, 187 participants developed MCI over a median of 8.1 years of follow-up. FR and DFR each predicted incident MCI adjusting for age, sex, and education. Also, each independently predicted incident MCI in the presence of the other with similar effect sizes: around 20% decrease in the hazard of MCI corresponding to one standard deviation increase in FR or DFR.

conclusionThe practice of preferring retention over learning to predict incident MCI should be reconsidered. The decision to include retention should be guided by time constraints and patient burden.

Indexed as

Alzheimer DiseaseCognitive DysfunctionAgedCuesDisease ProgressionFemaleHumansLongitudinal StudiesMaleNeuropsychological TestsPrognosisAlzheimer’s diseaseFree and Cued Selective Reminding TestMemory disordersMild cognitive impairmentPreclinical dementiaProspective studiesRetentionVerbal learning

Identifiers

PMID33745492
PMCPMC8455713

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.