Evidence map›Paper›PMID 33745487›Full record

ArticleDevelopment and psychopathology2022

Prefrontal cortex and amygdala anatomy in youth with persistent levels of harsh parenting practices and subclinical anxiety symptoms over time during childhood.

Sabrina Suffren, Valérie La Buissonnière-Ariza, Alan Tucholka, Marouane Nassim, Jean R Séguin, Michel Boivin, Manpreet Kaur Singh, Lara C Foland-Ross, Franco Lepore, Ian H Gotlib and 2 more

Abstract read
In one paragraph

Article in Development and psychopathology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. [Bayesian network analysis of harsh parenting, experiential avoidance, and adolescent short video addiction risk].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2026
    Article
  4. Article
  5. Review
  6. Parent Psychopathology and Behavioral Effects on Child Brain-Symptom Networks in the ABCD Study.Journal of the American Academy of Child and Adolescent Psychiatry · 2024
    Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Sabrina SuffrenResearch Center, Sainte-Justine Hospital, University of Montreal, Canada.ORCID 0000-0001-8359-5756
Valérie La Buissonnière-ArizaResearch Center, Sainte-Justine Hospital, University of Montreal, Canada.ORCID 0000-0001-9071-9833
Alan TucholkaResearch Center, Sainte-Justine Hospital, University of Montreal, Canada.
Marouane NassimResearch Center, Sainte-Justine Hospital, University of Montreal, Canada.
Jean R SéguinResearch Center, Sainte-Justine Hospital, University of Montreal, Canada.
Michel BoivinResearch Group on Children's Psychosocial Maladjustment, University of Montreal, Canada.
Manpreet Kaur SinghDepartment of Psychiatry and Behavioral Sciences, School of Medicine, Stanford, CA, USA.
Lara C Foland-RossDepartment of Psychiatry and Behavioral Sciences, School of Medicine, Stanford, CA, USA.
Franco LeporeResearch Center, Sainte-Justine Hospital, University of Montreal, Canada.
Ian H GotlibDepartment of Psychology, Stanford University, Stanford, CA, USA.
Richard E TremblayResearch Center, Sainte-Justine Hospital, University of Montreal, Canada.
Françoise S MaheuResearch Center, Sainte-Justine Hospital, University of Montreal, Canada.

Funding

Psychobiological Mechanisms Underlying the Association Between Early Life Stress and Depression Across AdolescenceR37MH101495 · NIMH · STANFORD UNIVERSITY · PI IAN H GOTLIB · 2018 to 2026
$6.6M
CIHR HDF-70335CIHR MOP-44072CIHR MOP-97983NIMH NIH HHS R37 MH101495
6 · The paper itself

Abstract

Childhood adversity and anxiety have been associated with increased risk for internalizing disorders later in life and with a range of brain structural abnormalities. However, few studies have examined the link between harsh parenting practices and brain anatomy, outside of severe maltreatment or psychopathology. Moreover, to our knowledge, there has been no research on parenting and subclinical anxiety symptoms which remain persistent over time during childhood (i.e., between 2.5 and 9 years old). Here, we examined data in 94 youth, divided into four cells based on their levels of coercive parenting (high / low) and of anxiety (high / low) between 2.5 and 9 years old. Anatomical images were analyzed using voxel-based morphometry (VBM) and FreeSurfer. Smaller gray matter volumes in the prefrontal cortex regions and in the amygdala were observed in youth with high versus low levels of harsh parenting over time. In addition, we observed significant interaction effects between parenting practices and subclinical anxiety symptoms in rostral anterior cingulate cortical thickness and in amygdala volume. These youth should be followed further in time to identify which youth will or will not go on to develop an anxiety disorder, and to understand factors associated with the development of sustained anxiety psychopathology.

Indexed as

Magnetic Resonance ImagingParentingAdolescentAmygdalaAnxietyChildChild, PreschoolHumansPrefrontal CortexanxietyFreeSurferinternalized disordersparental practicesVBM

Identifiers

PMID33745487
PMCPMC11784656

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.