Evidence map›Paper›PMID 33745293›Full record

ArticleJournal of the American Heart Association2021

Abnormal Left-Hemispheric Sulcal Patterns in Adults With Simple Congenital Heart Defects Repaired in Childhood.

Benjamin Asschenfeldt, Lars Evald, Hyuk Jin Yun, Johan Heiberg, Leif Østergaard, P Ellen Grant, Vibeke Elisabeth Hjortdal, Kiho Im, Simon Fristed Eskildsen

Open access · goldAbstract read
In one paragraph

Article in Journal of the American Heart Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. [Research progress on neurodevelopmental disorders associated with congenital heart disease].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2024
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Brain MRI Radiomics Analysis of School-Aged Children with Tetralogy of Fallot.Computational and mathematical methods in medicine · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Benjamin AsschenfeldtDepartment of Cardiothoracic and Vascular Surgery Aarhus University Hospital Aarhus N Denmark.
Lars EvaldDepartment of Clinical Medicine Aarhus University Aarhus N Denmark.
Hyuk Jin YunFetal Neonatal Neuroimaging and Developmental Science Center Boston Children's Hospital Boston MA.
Johan HeibergDepartment of Cardiothoracic and Vascular Surgery Aarhus University Hospital Aarhus N Denmark.
Leif ØstergaardDepartment of Clinical Medicine Aarhus University Aarhus N Denmark.
P Ellen GrantFetal Neonatal Neuroimaging and Developmental Science Center Boston Children's Hospital Boston MA.
Vibeke Elisabeth HjortdalDepartment of Clinical Medicine Aarhus University Aarhus N Denmark.
Kiho ImFetal Neonatal Neuroimaging and Developmental Science Center Boston Children's Hospital Boston MA.
Simon Fristed EskildsenDepartment of Clinical Medicine Aarhus University Aarhus N Denmark.
Aarhus University · DKBoston Children's Hospital · USUniversity of Copenhagen · DK

Funding

Genetic and Hemodynamic Effects on Prenatal Cortical Development in Congenital Heart DiseaseR01NS114087 · NINDS · BOSTON CHILDREN'S HOSPITAL · PI IM, KIHO · 2020 to 2024
$2.8M
NINDS NIH HHS R01 NS114087
6 · The paper itself

Abstract

Background Children operated on for a simple congenital heart defect (CHD) are at risk of neurodevelopmental abnormalities. Abnormal cortical development and folding have been observed in fetuses with CHD. We examined whether sulcal folding patterns in adults operated on for simple CHD in childhood differ from those of healthy controls, and whether such differences are associated with neuropsychological outcomes. Methods and Results Patients (mean age, 24.5 years) who underwent childhood surgery for isolated atrial septal defect (ASD; n=33) or ventricular septal defect (VSD; n=30) and healthy controls (n=37) were enrolled. Sulcal pattern similarity to healthy controls was determined using magnetic resonance imaging and looking at features of sulcal folds, their intersulcal relationships, and sulcal graph topology. The sulcal pattern similarity values were tested for associations with comprehensive neuropsychological scores. Patients with both ASD and VSD had decreased sulcal pattern similarity in the left hemisphere compared with controls. The differences were found in the left temporal lobe in the ASD group and in the whole left hemisphere in the VSD group (

Indexed as

AdultCardiac Surgical ProceduresCase-Control StudiesCerebral CortexChildChild, PreschoolCross-Sectional StudiesExecutive FunctionFemaleFollow-Up StudiesForecastingHeart Defects, CongenitalHeart Septal Defects, AtrialHeart Septal Defects, VentricularHumansIntelligenceadultbraincongenital heart defectmagnetic resonance imagingsulcal pattern

Identifiers

PMID33745293
PMCPMC8174332
OpenAlexW3136621030

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.