Evidence map›Paper›PMID 33745226›Full record

ArticlePediatric diabetes2021

Diabetic ketoacidosis at type 1 diabetes diagnosis in children during the COVID-19 pandemic.

Josephine Ho, Elizabeth Rosolowsky, Daniele Pacaud, Carol Huang, Julie-Anne Lemay, Nicole Brockman, Mitchell Rath, Manpreet Doulla

Abstract readMulticenter Study
In one paragraph

Article in Pediatric diabetes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
68citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

68 citing papers in PubMed, 7 syntheses or guidelines pooled it.

  1. Pediatric endocrinopathies related to COVID-19: an update.World journal of pediatrics : WJP · 2023
    Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Article
  9. Observational
  10. Ketoacidosis in new-onset type 1 diabetes: return to pre-COVID-19 pandemic reality?Pediatric endocrinology, diabetes, and metabolism · 2026
    Observational
  11. Review
  12. Article
  13. Article
  14. Observational
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Covid 19 and diabetes in children: advances and strategies.Diabetology & metabolic syndrome · 2024
    Review

8 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Josephine HoDivision of Pediatric Endocrinology, Department of Pediatrics, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.ORCID 0000-0003-0379-4427
Elizabeth RosolowskyDivision of Pediatric Endocrinology, Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.ORCID 0000-0002-0402-4240
Daniele PacaudDivision of Pediatric Endocrinology, Department of Pediatrics, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.ORCID 0000-0001-6337-7241
Carol HuangDivision of Pediatric Endocrinology, Department of Pediatrics, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Julie-Anne LemayUniversity of Calgary, Calgary, Alberta, Canada.
Nicole BrockmanUniversity of Alberta, Edmonton, Alberta, Canada.
Mitchell RathUniversity of Calgary, Calgary, Alberta, Canada.
Manpreet DoullaDivision of Pediatric Endocrinology, Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.ORCID 0000-0001-5574-7863

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe COVID-19 pandemic has led to significant public health measures that have resulted in decreased acute pediatric care utilization. We evaluated whether the rate of severe presentations of new onset type 1 diabetes (DM1), such as, diabetic ketoacidosis (DKA) has changed since the COVID-19 public health measures were enacted. RESEARCH DESIGN AND

methodsA retrospective chart review of children less than 18 years of age presenting with new onset DM1 during the pandemic period of March 17, 2020 to August 31, 2020 was conducted at two tertiary care pediatric hospitals in Alberta, Canada. Rates of DKA and severe DKA were compared to the same time period in the year 2019 (pre-pandemic control).

resultsThe number of children presenting with newly diagnosed DM1 was similar during the pandemic year of 2020 compared with 2019 (107 children in 2020 vs. 114 in 2019). The frequency of DKA at DM1 onset was significantly higher in the pandemic period (68.2% vs 45.6%; p < 0.001) and incidence of severe DKA was also higher (27.1% in 2020 vs 13.2% in 2019; p = 0.01).

conclusionsThere was a significant increase in DKA and severe DKA in children presenting with new onset DM1 during the COVID-19 pandemic period. This emphasizes the need for educating health care professionals and families to be aware of the symptoms of hyperglycemia and the importance of early diagnosis and treatment even during public health measures for COVID-19.

Indexed as

SARS-CoV-2AdolescentAlbertaBlood Glucose Self-MonitoringChildChild, PreschoolCOVID-19Diabetes Mellitus, Type 1Diabetic KetoacidosisFemaleHumansIntensive Care Units, PediatricMalePandemicsRetrospective StudiesChildrenCOVID-19diabetesdiabetic ketoacidosispandemic

Identifiers

PMID33745226
PMCPMC8251027

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.