ReviewInfection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases2021
Understanding the origin of COVID-19 requires to change the paradigm on zoonotic emergence from the spillover to the circulation model.
Review in Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Meta-analysis to explain unknown causes of the origins of SARS-COV-2.Environmental research · 2022Pooled it
- The reverse zoonotic potential of SARS-CoV-2.Heliyon · 2024Review
- Molecular surveillance of potential SARS-CoV-2 reservoir hosts in wildlife rehabilitation centers.The veterinary quarterly · 2023Article
- Pillars for successful operationalization of one health as an ecosystem approach: experience from a human-animal interface in the Maasai steppe in Tanzania.One health outlook · 2023Article
- Unravelling Antigenic Cross-Reactions toward the World of Coronaviruses: Extent of the Stability of Shared Epitopes and SARS-CoV-2 Anti-Spike Cross-Neutralizing Antibodies.Pathogens (Basel, Switzerland) · 2023Review
- Psittacosis contagion in 1930: an old story in a new era of zoonotic disease.Microbes and infection · 2023Article
- ACE2 receptor polymorphism in humans and animals increases the risk of the emergence of SARS-CoV-2 variants during repeated intra- and inter-species host-switching of the virus.Frontiers in microbiology · 2023Article
- An updated review of the scientific literature on the origin of SARS-CoV-2.Environmental research · 2022Review
- Non-uniform aspects of the SARS-CoV-2 intraspecies evolution reopen question of its origin.International journal of biological macromolecules · 2022Article
- Lost Lessons of the 1918 Influenza: The 1920s Working Hypothesis, the Public Health Paradigm, and the Prevention of Deadly Pandemics.American journal of public health · 2022Article
- The stochastic world of emerging viruses.PNAS nexus · 2022Article
- Assessing the risk of human-to-wildlife pathogen transmission for conservation and public health.Ecology letters · 2022Review
- The COVID-19 pandemic, an environmental neurology perspective.Revue neurologique · 2022Review
- Cats and SARS-CoV-2: A Scoping Review.Animals : an open access journal from MDPI · 2022Article
- Averting wildlife-borne infectious disease epidemics requires a focus on socio-ecological drivers and a redesign of the global food system.EClinicalMedicine · 2022Review
- There is no "origin" to SARS-CoV-2.Environmental research · 2022Article
- A mathematical-adapted model to analyze the characteristics for the mortality of COVID-19.Scientific reports · 2022Article
- Origin of COVID-19: Dismissing the Mojiang mine theory and the laboratory accident narrative.Environmental research · 2022Article
- Article
- Influence of mobility restrictions on air quality in the historic center of Cuenca city and its inference on the Covid-19 rate infections.Materials today. Proceedings · 2022Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
While the COVID-19 pandemic continues to spread with currently more than 117 million cumulated cases and 2.6 million deaths worldwide as per March 2021, its origin is still debated. Although several hypotheses have been proposed, there is still no clear explanation about how its causative agent, SARS-CoV-2, emerged in human populations. Today, scientifically-valid facts that deserve to be debated still coexist with unverified statements blurring thus the knowledge on the origin of COVID-19. Our retrospective analysis of scientific data supports the hypothesis that SARS-CoV-2 is indeed a naturally occurring virus. However, the spillover model considered today as the main explanation to zoonotic emergence does not match the virus dynamics and somehow misguided the way researches were conducted. We conclude this review by proposing a change of paradigm and model and introduce the circulation model for explaining the various aspects of the dynamic of SARS-CoV-2 emergence in humans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.