Evidence map›Paper›PMID 33744279›Full record

ArticleToxicology and applied pharmacology2021

Toxicokinetic evaluation of the common indoor air pollutant, α-pinene, and its potential reactive metabolite, α-pinene oxide, following inhalation exposure in rodents.

Suramya Waidyanatha, Michael Hackett, Sherry R Black, Mathew D Stout, Timothy R Fennell, Melanie R Silinski, Scott L Watson, Joseph Licause, Veronica G Robinson, Barney Sparrow and 3 more

Open access · greenAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxicology and applied pharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. The common indoor air pollutant α-pinene is metabolised to a genotoxic metabolite α-pinene oxide.Xenobiotica; the fate of foreign compounds in biological systems · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Suramya WaidyanathaDivision of the National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA. Electronic address: waidyanathas@niehs.nih.gov.
Michael HackettBattelle, Columbus, OH, USA.
Sherry R BlackRTI International, Research Triangle Park, NC, USA.
Mathew D StoutDivision of the National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA.
Timothy R FennellRTI International, Research Triangle Park, NC, USA.
Melanie R SilinskiRTI International, Research Triangle Park, NC, USA.
Scott L WatsonRTI International, Research Triangle Park, NC, USA.
Joseph LicauseRTI International, Research Triangle Park, NC, USA.
Veronica G RobinsonDivision of the National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA.
Barney SparrowBattelle, Columbus, OH, USA.
Reshan A FernandoRTI International, Research Triangle Park, NC, USA.
Stephen CooperRTI International, Research Triangle Park, NC, USA.
Cynthia V RiderDivision of the National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA.
RTI International · USNational Institute of Environmental Health Sciences · USBattelle · US

Funding

Toxicological Assessments for the National Toxicology ProgramZIAES103316 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI WALKER, NIGEL J · 2016 to 2019
$31.9M
Toxicological Assessments for the Division of the National Toxicology ProgramZICES103316 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI WALKER, NIGEL J · 2020 to 2021
$18.5M
Intramural NIH HHS ZIA ES103316NIEHS NIH HHS HHSN273201400015CNIEHS NIH HHS HHSN273201400022C
6 · The paper itself

Abstract

The toxicokinetic behavior of α-pinene and its potential reactive metabolite, α-pinene oxide, was investigated following whole body inhalation exposure to 50 and 100 ppm α-pinene in rats and mice for 6 h per day for 7d. In both species and sexes, the maximum blood concentration (C

Indexed as

Air Pollution, IndoorActivation, MetabolicAir PollutantsAnimalsBicyclic MonoterpenesFemaleInhalation ExposureMaleMammary Glands, AnimalMiceRatsRats, Sprague-DawleyRisk AssessmentSex FactorsSpecies SpecificityTissue Distribution2-pinene oxideAir Pollutantsalpha-pineneBicyclic MonoterpenesInhalation exposureToxicokineticsα-Pineneα-pinene oxide

Identifiers

PMID33744279
PMCPMC8336714
OpenAlexW3136119820

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.