ReviewChild and adolescent psychiatric clinics of North America2021
How and Why Are Irritability and Depression Linked?
Review in Child and adolescent psychiatric clinics of North America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 52 citations in OpenAlex.
- Understanding irritability through the lens of self-regulatory control processes in children and adolescents: a systematic review.European child & adolescent psychiatry · 2025Pooled it
- Annual Research Review: What processes are dysregulated among emotionally dysregulated youth? - a systematic review.Journal of child psychology and psychiatry, and allied disciplines · 2025Pooled it
- Neural Responses to Intranasal Oxytocin in Youths With Severe Irritability.The American journal of psychiatry · 2024Trial
- Article
- ADHD in Youth With Major Depressive Disorder in the Texas Youth Depression and Suicide Research Network (TX-YDSRN): Clinical Correlates and Moderators.Journal of attention disorders · 2025Article
- Trajectory of Irritability in Autistic and Typically Developing Youth From Early Childhood to Adolescence.Autism research : official journal of the International Society for Autism Research · 2025Article
- Network analysis of central symptoms in Chinese young adults with subthreshold depression.Translational psychiatry · 2025Article
- Network analysis of loneliness, mental, and physical health in Czech adolescents.Child and adolescent psychiatry and mental health · 2025Article
- Network Analysis of Anxiety, Insomnia, Depression, and Suicide Attempts in Chinese Outpatients with Somatic Symptom Disorder.Neuropsychiatric disease and treatment · 2025Article
- Prevalence and correlates of irritability among U.S. adults.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Factors Associated with High Parent- and Youth-Rated Irritability Score in Early-Onset Mood Disorders: A Cross-Sectional Study with the Affective Reactivity Index (ARI).Brain sciences · 2024Article
- Day-to-day bidirectional associations between sleep and emotion states in early childhood: Importance of end-of-day mood for sleep quality.Sleep health · 2024Article
- Phasic Versus Tonic Irritability and Associations with Family Accommodation Among Youth with Selective Mutism: A Latent Profile Analysis.Research on child and adolescent psychopathology · 2024Article
- Appetite hormone dysregulation and executive dysfunction among adolescents with bipolar disorder and disruptive mood dysregulation disorder.European child & adolescent psychiatry · 2024Article
- The moderating effect of psychological distress in the association between temperaments and dark future among young adults.BMC psychiatry · 2024Article
- Negative Emotions Are Associated With Older Self-perceived Age: A Cross-section Study From the UK Biobank.International journal of health policy and management · 2024Article
- Disruptive mood dysregulation disorder, parental stress, and attachment styles.Frontiers in child and adolescent psychiatry · 2024Article
- Within-person pathways among maternal depressive symptoms and offspring internalizing problems from early childhood through adolescence.Development and psychopathology · 2023Article
- Longitudinal associations between early childhood irritability and adolescent depression symptoms in autistic children are mediated by peer relationships but not educational engagement.Development and psychopathology · 2023Article
- Keeping up with the kids: the value of co-production in the study of irritability in youth depression and its underlying neural circuitry.Frontiers in behavioral neuroscience · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Based on its course over time, irritability is linked to depression cross-sectionally and longitudinally. Cross-sectionally, irritability takes an episodic form as a symptom in pediatric depression; yet, irritability in the absence of depressed mood or anhedonia is rare. Longitudinally, chronic irritability has been shown to predict depression rather than bipolar disorder or externalizing disorders. Evidence suggests that the link between irritability and depression is explained mostly by shared genetic risk. Both conditions are also associated with higher rates of family history of depression, childhood temperaments and personality styles, and negative parenting styles. The treatment implications are discussed.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.