ArticleInfectious diseases of poverty2021
Control trial of porcine cysticercosis in Uganda using a combination of the TSOL18 vaccination and oxfendazole.
Article in Infectious diseases of poverty, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Neurocysticercosis control for primary epilepsy prevention: a systematic review.Pathogens and global health · 2022Pooled it
- Extraneural cysticercosis mimicking soft-tissue tumors: a case report from a low-resource setting.International journal of surgery case reports · 2026Article
- Supply chains and delivery systems for pig vaccines in Uganda - Challenges and solutions.The Onderstepoort journal of veterinary research · 2026Article
- In vitro screening of the open-access Pandemic Response Box reveals ESI-09 as a compound with activity against Echinococcus multilocularis.International journal for parasitology. Drugs and drug resistance · 2025Article
- Integrating neurological expertise into One Health strategies for pediatric neurocysticercosis-associated epilepsy control in Sub-Saharan Africa: a narrative review.One health outlook · 2025Review
- Evaluation of a One Health public health program based on minimum inputs to control Taenia solium in Madagascar.PLoS neglected tropical diseases · 2025Article
- Long-Term Neuroimaging Findings in a Murine Model of Human Extraparenchymal Neurocysticercosis.ACS infectious diseases · 2025Article
- Aggregation ofParasite epidemiology and control · 2023Review
- Confirmation by necropsy of a high prevalence of porcine cysticercosis in a rural district of Madagascar.Parasitology · 2023Article
- Article
- Structure of the pork value chain in Northern Uganda: implications forFrontiers in veterinary science · 2023Article
- Maximising Societal Benefit From the Control of Neglected Zoonoses: Identifying Synergies and Trade-Offs in the Control ofFrontiers in veterinary science · 2021Review
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 3 countries.
Funding
Abstract
backgroundNeurocysticercosis caused by Taenia solium when the parasite lodges in the central nervous system, is an important cause of human seizures and mortality in sub-Saharan Africa. The parasite is prevalent in many regions of Uganda. Pigs are intermediate hosts for T. solium, and we evaluated a T. solium control program in pigs, involving vaccination of pigs with the TSOL18 vaccine and treatment with oxfendazole.
methodsThe study was conducted in two districts of Eastern Uganda involving the rural village communities of Bukedea (intervention area) and Kumi (control area) during 2016-2017. Seven hundred and thirty-four households were enrolled in the study. Pigs in the intervention area received intramuscular immunizations with TSOL18 (Cysvax™) and an oral medication with 30 mg/kg oxfendazole (Paranthic™) at approximately 3-monthly intervals for 18 months. Porcine cysticercosis was evaluated by post-mortem examination. At the beginning of the study, 111 pigs were examined. In an interim evaluation in the intervention area, 55 pigs were evaluated 12 months after starting the project. At the end of the study approximately 3 months after the final intervention, 55 pigs from the intervention area and 56 pigs from the control area were evaluated.
resultsThe prevalence of porcine cysticercosis for the two sites was 16.2% at the beginning of the study (17.2% in the intervention area and 15.1% in the control area) with no statistically significant difference (P = 0.759) between the two study sites. Among the 110 animals assessed from the intervention site (55 at the interim evaluation and 55 at the final evaluation), no pig with viable T. solium cysts was found. There was a statistically significant difference between the prevalence at baseline (17.2%) and at the end of the study (0%) in the intervention area (P = 0.001) and a statistically significant difference between the intervention (0%) and control areas (5.4%) (P = 0.041) at the end of the study.
conclusionsThree-monthly concurrent vaccination of pigs with the TSOL18 vaccine and medication with oxfendazole eliminated T. solium transmission by the animals involved in the study. Application of vaccination with medication in pigs has the potential to reduce transmission of T. solium in Uganda and other endemic countries.
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