SynthesisSystematic reviews2021
The effect of age on the incidence of COVID-19 complications: a systematic review and meta-analysis.
Synthesis in Systematic reviews, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Cardiac Injury in COVID-19: A Systematic Review of Relevant Meta-Analyses.Reviews in cardiovascular medicine · 2022Pooled it
- Work-Related Exposures Mediate Occupational Class Disparities in SARS-CoV-2 Infection in France.International journal of public health · 2026Article
- Predictors of Unfavorable Outcomes in COVID-19-Related Sepsis: A Prospective Cohort Study.Viruses · 2025Article
- Spatio-temporal forecasting of COVID-19 cases in the Netherlands for source and contact tracing.International journal of population data science · 2025Article
- A framework for modeling county-level COVID-19 transmission.Frontiers in public health · 2025Article
- What proteins and albumins in bronchoalveolar lavage fluid and serum could tell us in COVID-19 and influenza acute respiratory distress syndrome on mechanical ventilation patient - A prospective double center study.Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures) · 2025Article
- Socio-demographic and clinical predictors of post-acute, mid-and long-term psychological sequelae of COVID-19: a two-year cross-sectional investigation on 1317 patients at the University Hospital of Verona.Archives of public health = Archives belges de sante publique · 2024Article
- Motor and Respiratory Tele-Rehabilitation in Patients with Long COVID-19 after Hospital Discharge: An Interventional Study.Life (Basel, Switzerland) · 2024Article
- Prediction equations for detecting COVID-19 infection using basic laboratory parameters.Journal of family medicine and primary care · 2024Article
- COVID-19 and cancer risk arising from ionizing radiation exposure through CT scans: a cross-sectional study.BMC cancer · 2024Article
- A High Respiratory Drive Is Associated with Weaning Failure in Patients with COVID-19-Associated Acute Respiratory Distress Syndrome: The Role of the Electrical Activity of the Diaphragm.Journal of clinical medicine · 2024Article
- Outcomes of adults hospitalized with COVID-19 at the University Teaching Hospital of Butare in Rwanda and validation of the Universal Vital Assessment (UVA) mortality risk score.PLOS global public health · 2024Article
- Specific persistent symptoms of COVID-19 and associations with reinfection: a community-based survey study in southern China.Frontiers in public health · 2024Article
- Tele-Rehabilitation Interventions for Motor Symptoms in COVID-19 Patients: A Narrative Review.Bioengineering (Basel, Switzerland) · 2023Review
- Incidence and risk factors of pressure injuries in critically ill patients with COVID-19.Revista brasileira de enfermagem · 2023Article
- Long-term mortality following SARS-CoV-2 infection: A national cohort study from Estonia.The Lancet regional health. Europe · 2022Article
- Article
- The Use of Mebendazole in COVID-19 Patients: An Observational Retrospective Single Center Study.Advances in virology · 2022Article
- Clinical profile, treatment, and outcomes of patients with COVID-19 in a tertiary referral hospital in South Sumatera, Indonesia: A retrospective single-center study.Belitung nursing journal · 2022Article
- COVID-19 and Preexisting Comorbidities: Risks, Synergies, and Clinical Outcomes.Frontiers in immunology · 2022Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe coronavirus (COVID-19) pandemic was reported from Wuhan, China, on December 31, 2019, and the pandemic was spread to more than 212 countries in the globe. This meta-analysis aimed to assess the pooled incidence of COVID-19 complications and to identify the association between the incidence of complications and age.
methodsComprehensive databases, PubMed, Hinari, and Google Scholar, were used to locate potential articles for this review. Data were extracted using Microsoft Excel and imported to the STATA/MP version 16.0 software for analysis. Heterogeneity between studies was assessed using the Cochrane Q test statistics and I
resultsFrom the total of 1237 studies, 12 studies were included with a total of 3064 COVID-19 patients. The most complications were acute respiratory distress syndrome (30.93%, 95%CI 21.3-40.6%) followed by acute liver injury (22.8%, 95%CI 14-31.5%), shock (10.9%, 95%CI 7.4-14.4%), acute kidney injury (7%, 95%CI 3.8-10.4%), and acute cardiac injury (6.4%, 95%CI 2.8-15.6%). Univariate meta-regression revealed that as the mean age increased by 1 year, the incidence of acute respiratory distress syndrome, acute kidney injury, acute cardiac injury, and shock increased by a factor of 2.9 (β = 2.9, 95%CI 2.4-3.4, adjusted R
conclusionSignificant complications of COVID-19 viral infections were reported. Older populations were a high-risk group of developing adverse complications as compared to their counterparts. Health care professionals should give primary attention to those risk group individuals.
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Registered trials
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