Evidence map›Paper›PMID 33743812›Full record

ArticleCritical care (London, England)2021

Mechanical ventilation parameters in critically ill COVID-19 patients: a scoping review.

Giacomo Grasselli, Emanuele Cattaneo, Gaetano Florio, Mariachiara Ippolito, Alberto Zanella, Andrea Cortegiani, Jianbo Huang, Antonio Pesenti, Sharon Einav

Open access · goldAbstract readScoping Review
In one paragraph

Article in Critical care (London, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
69citing papers in PubMed, 1 pooled it
18.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

69 citing papers in PubMed, 1 synthesis or guideline pooled it, 132 citations in OpenAlex.

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9 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 3 countries.

Giacomo GrasselliDepartment of Pathophysiology and Transplantation, University of Milan, Milan, Italy. giacomo.grasselli@unimi.it.ORCID 0000-0002-1735-1400
Emanuele CattaneoDipartimento Di Anestesia, Rianimazione ed Emergenza-Urgenza, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Via Francesco Sforza 35, 20122, Milan, Italy.
Gaetano FlorioDepartment of Pathophysiology and Transplantation, University of Milan, Milan, Italy.
Mariachiara IppolitoDepartment of Surgical, Oncological and Oral Science (Di.Chir.On.S.), University of Palermo, Palermo, Italy.
Alberto ZanellaDepartment of Pathophysiology and Transplantation, University of Milan, Milan, Italy.
Andrea CortegianiDepartment of Surgical, Oncological and Oral Science (Di.Chir.On.S.), University of Palermo, Palermo, Italy.
Jianbo HuangDepartment of General Surgery, The First Affiliated Hospital, Chongqing Medical University, Chongqing, China.
Antonio PesentiDepartment of Pathophysiology and Transplantation, University of Milan, Milan, Italy.
Sharon EinavGeneral Intensive Care Unit, Shaare Zedek Medical Center, Jerusalem, Israel.
University of Milan · ITAzienda Ospedaliera Universitaria Policlinico "Paolo Giaccone" di Palermo · ITFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico · ITHebrew University of Jerusalem · ILThe Affiliated Yongchuan Hospital of Chongqing Medical University · CNUniversity of Palermo · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe mortality of critically ill patients with COVID-19 is high, particularly among those receiving mechanical ventilation (MV). Despite the high number of patients treated worldwide, data on respiratory mechanics are currently scarce and the optimal setting of MV remains to be defined. This scoping review aims to provide an overview of available data about respiratory mechanics, gas exchange and MV settings in patients admitted to intensive care units (ICUs) for COVID-19-associated acute respiratory failure, and to identify knowledge gaps. MAIN TEXT: PubMed, EMBASE, and MEDLINE databases were searched from inception to October 30, 2020 for studies providing at least one ventilatory parameter collected within 24 h from the ICU admission. The quality of the studies was independently assessed using the Newcastle-Ottawa Quality Assessment Form for Cohort Studies. A total of 26 studies were included for a total of 14,075 patients. At ICU admission, positive end expiratory pressure (PEEP) values ranged from 9 to 16.5 cm of water (cmH

conclusionsAvailable data show that, in mechanically ventilated patients with COVID-19, respiratory mechanics and MV settings within 24 h from ICU admission are heterogeneous but similar to those reported for "classical" ARDS. However, to date, complete data regarding mechanical properties of respiratory system, optimal setting of MV and the role of rescue treatments for refractory hypoxemia are still lacking in the medical literature.

Indexed as

Respiration, ArtificialCOVID-19Critical IllnessHumansIntensive Care UnitsRespiratory Distress SyndromeRespiratory MechanicsAcute respiratory distress syndromeCoronavirus disease 2019Intensive care unitsMechanical ventilation

Identifiers

PMID33743812
PMCPMC7980724
OpenAlexW3138469621

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.