Evidence map›Paper›PMID 33743717›Full record

ArticlePediatric rheumatology online journal2021

Disease activity index is associated with subclinical atherosclerosis in childhood-onset systemic lupus erythematosus.

Priscila B S Medeiros, Roberta G Salomão, Sara R Teixeira, Diane M Rassi, Luciana Rodrigues, Davi C Aragon, Priscila G Fassini, Fábio V Ued, Rita C Tostes, Jacqueline P Monteiro and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric rheumatology online journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Guideline
  2. Trial
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Priscila B S MedeirosDepartment of Pediatrics, University of São Paulo, Av. Bandeirantes, 3900, Ribeirão Preto, São Paulo, 14049-900, Brazil.
Roberta G SalomãoDivision of Nutrition and Metabolism, Department of Health Sciences, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
Sara R TeixeiraDepartment of Medical Imaging, Oncology and Hematology, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
Diane M RassiDepartment of Pharmacology, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
Luciana RodriguesDepartment of Pediatrics, University of São Paulo, Av. Bandeirantes, 3900, Ribeirão Preto, São Paulo, 14049-900, Brazil.
Davi C AragonDepartment of Pediatrics, University of São Paulo, Av. Bandeirantes, 3900, Ribeirão Preto, São Paulo, 14049-900, Brazil.
Priscila G FassiniDepartment of Internal Medicine, Division of Nutrology, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
Fábio V UedDivision of Nutrition and Metabolism, Department of Health Sciences, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
Rita C TostesDepartment of Pharmacology, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
Jacqueline P MonteiroDepartment of Pediatrics, University of São Paulo, Av. Bandeirantes, 3900, Ribeirão Preto, São Paulo, 14049-900, Brazil.
Virgínia P L FerrianiDepartment of Pediatrics, University of São Paulo, Av. Bandeirantes, 3900, Ribeirão Preto, São Paulo, 14049-900, Brazil.
Luciana M de CarvalhoDepartment of Pediatrics, University of São Paulo, Av. Bandeirantes, 3900, Ribeirão Preto, São Paulo, 14049-900, Brazil. lucianamartinscarvalho@usp.br.ORCID http://orcid.org/0000-0002-0114-2735
Universidade de São Paulo · BR

Funding

CNPq 400913/2016-0
6 · The paper itself

Abstract

backgroundSystemic lupus erythematosus (SLE) is an independent risk factor for cardiovascular events. The present study determined the prevalence of subclinical atherosclerosis in childhood-onset SLE using the carotid intima-media thickness (CIMT) measurement and investigated associations between traditional and nontraditional risk factors for atherosclerosis, such as medications, SLE Disease Activity Index - SLEDAI-2 K and SLICC-ACR damage index and CIMT.

methodsCross-sectional prospective study between 2017 and 2018. CIMT was assessed by ultrasonography. Data were collected by chart review, nutritional evaluation and laboratory tests and analyzed by Fisher, Wilcoxon-Mann-Whitney tests, multiple linear and log binomial regression.

resultsTwenty-eight patients (mean age 13.9 years, SD 3) were enrolled. The prevalence of subclinical atherosclerosis was 32% (95% CI 14.8, 49.4). The mean CIMT was 0.43 ± 0.035 mm. The most common traditional risk factors observed were dyslipidemia (82.1%), uncontrolled hypertension (14.2%), obesity (14.3%), and poor diet (78.6%). Uncontrolled hypertension (p = 0.04), proteinuria (p = 0.02), estimated glomerular filtration rate < 75 ml /min/1.73 m

conclusionSubclinical atherosclerosis is frequently observed in cSLE, mainly in patients with moderate to severe disease activity.

Indexed as

AdolescentAtherosclerosisCarotid Intima-Media ThicknessChildCross-Sectional StudiesFemaleHumansLupus Erythematosus, SystemicMalePrevalenceProspective StudiesRisk FactorsYoung AdultAtherosclerosisCarotid intima-media thicknessLupus Erythematosus, systemic, childhoodNutritional assessment

Identifiers

PMID33743717
PMCPMC7981852
OpenAlexW2951938235

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.