ArticleBMC gastroenterology2021
Whipple's disease: the great masquerader-a high level of suspicion is the key to diagnosis.
Article in BMC gastroenterology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 25 citations in OpenAlex.
- When it's not RA: unmasking Whipple's disease in seronegative, difficult-to-treat rheumatoid arthritis.Clinical rheumatology · 2026Review
- Deciphering whipple's disease complexity.Clinical and experimental medicine · 2026Review
- TimeX: Phenotype Onset Extraction from Clinical Narratives.npj health systems · 2026Article
- Whipple Disease Initial Presentation as Supraclavicular Lymphadenopathy in a Patient With Rheumatoid Arthritis: A Diagnostic Challenge.International journal of surgical pathology · 2025Article
- Large language models for clinical decision support in gastroenterology and hepatology.Nature reviews. Gastroenterology & hepatology · 2025Review
- Article
- ExploringFrontiers in pharmacology · 2025Article
- Whipple Disease With Central Nervous System Involvement.Federal practitioner : for the health care professionals of the VA, DoD, and PHS · 2024Article
- Article
- Whipple's Disease Mimicking Sarcoidosis.Cureus · 2023Article
- Article
- Tropheryma whipplei in the stool samples of children with acute diarrhea: a study from Tehran, Iran.BMC infectious diseases · 2022Article
- Review
- Clinical manifestations of Whipple's disease mimicking rheumatic disorders.Reumatologia · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWhipple's disease is a chronic infectious disease that primarily affects the small intestine, but several organs can simultaneously be involved. The disease is caused by a gram-positive bacterium called Tropheryma whipplei. The disease is difficult to suspect because it is rare with unspecific and long-term symptoms; it can be lethal if not properly treated. CASE PRESENTATION: We here present three patients who presented with a plethora of symptoms, mainly long-standing seronegative arthritis and gastrointestinal symptoms in the form of diarrhea with blood, weight loss, fever, and lymphadenopathy. They were after extensive investigations diagnosed with Whipple's disease, in two of them as long as 8 years after the first occurrence of joint manifestations. The diagnosis was made by PCR targeting the T. whipplei 16S rRNA gene from small bowel specimen in all three patients, and, besides from histopathologic findings from the duodenum and distal ileum in one and mesenteric lymph nodes in another patient.
conclusionsThis report aims to raise awareness of a very rare disease that presents with a combination of symptoms mimicking other and significantly more common diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.