ArticleNeuroImage. Clinical2021
White matter hyperintensities classified according to intensity and spatial location reveal specific associations with cognitive performance.
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Article in NeuroImage. Clinical, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
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Who cites it
17 citing papers in PubMed, 25 citations in OpenAlex.
- Threshold Effects, Cognitive Decline, and Longitudinal Changes in White Matter Hyperintensity Volume.Stroke · 2026Article
- Exploring synaptic density patterns in cerebral small vessel disease: insights from [European journal of nuclear medicine and molecular imaging · 2026Article
- Associations of Regional White Matter Hyperintensities Severity with Different Visual Rating Scales and Domain-Specific Cognitive Impairment.Neurosciences (Riyadh, Saudi Arabia) · 2026Article
- Threshold Effects, Cognitive Decline, and Longitudinal Changes in White Matter Hyperintensity Volume.medRxiv : the preprint server for health sciences · 2025Article
- Heterogeneity of white matter hyperintensities in Alzheimer's disease captured by multimodal neuroimaging.Scientific reports · 2025Article
- Identifying sources of bias when testing three available algorithms for quantifying white matter lesions: BIANCA, LPA and LGA.GeroScience · 2025Article
- Disturbed neurovascular coupling in patients with white matter hyperintensities: potential biomarker for cognitive impairment.Neuroradiology · 2024Article
- Quantitative Analysis of White Matter Hyperintensities as a Predictor of 1-Year Risk for Ischemic Stroke Recurrence.Neurology and therapy · 2024Article
- A blood biomarker of the pace of aging is associated with brain structure: replication across three cohorts.Neurobiology of aging · 2024Article
- Specialized gray matter segmentation via a generative adversarial network: application on brain white matter hyperintensities classification.Frontiers in neuroscience · 2024Article
- Cocaine use is associated with cerebral white matter hyperintensities in HIV disease.Annals of clinical and translational neurology · 2023Article
- Cortical Thickness and Brain Connectivity Mediate the Relation Between White Matter Hyperintensity and Information Processing Speed in Cerebral Small Vessel Disease.Brain topography · 2023Article
- White matter microstructural correlates of associative learning in the oldest-old.Cognitive, affective & behavioral neuroscience · 2023Article
- Assessment of white matter hyperintensity severity using multimodal magnetic resonance imaging.Brain communications · 2023Article
- Adapting UK Biobank imaging for use in a routine memory clinic setting: The Oxford Brain Health Clinic.NeuroImage. Clinical · 2022Article
- Research Progress on MRI for White Matter Hyperintensity of Presumed Vascular Origin and Cognitive Impairment.Frontiers in neurology · 2022Review
- Age affects white matter microstructure and episodic memory across the older adult lifespan.Neurobiology of aging · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 7 institutions in 5 countries.
Luca MelazziniDepartment of Biomedical Sciences for Health, Università degli Studi di Milano, Milan, Italy; Wellcome Centre for Integrative Neuroimaging, Oxford Centre for Functional MRI of the Brain, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK. Electronic address: luca.melazzini@unimi.it.
Clare E MackayWellcome Centre for Integrative Neuroimaging, Oxford Centre for Functional MRI of the Brain, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK; Wellcome Centre for Integrative Neuroimaging, Oxford Centre for Human Brain Activity, Department of Psychiatry, University of Oxford, Oxford, UK; Oxford Health NHS Foundation Trust, Oxford, UK.
Valentina BordinWellcome Centre for Integrative Neuroimaging, Oxford Centre for Functional MRI of the Brain, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK; Department of Electronics, Information and Bioengineering, Politecnico di Milano, Milan, Italy.
Sana SuriWellcome Centre for Integrative Neuroimaging, Oxford Centre for Human Brain Activity, Department of Psychiatry, University of Oxford, Oxford, UK; Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, UK.
Enikő ZsoldosWellcome Centre for Integrative Neuroimaging, Oxford Centre for Functional MRI of the Brain, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK; Wellcome Centre for Integrative Neuroimaging, Oxford Centre for Human Brain Activity, Department of Psychiatry, University of Oxford, Oxford, UK; Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, UK.
Nicola FilippiniWellcome Centre for Integrative Neuroimaging, Oxford Centre for Human Brain Activity, Department of Psychiatry, University of Oxford, Oxford, UK.
Abda MahmoodDepartment of Psychiatry, Warneford Hospital, University of Oxford, Oxford, UK.
Vaanathi SundaresanWellcome Centre for Integrative Neuroimaging, Oxford Centre for Functional MRI of the Brain, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
Marina CodariDepartment of Radiology, Stanford University School of Medicine, Stanford, USA.
Eugene DuffWellcome Centre for Integrative Neuroimaging, Oxford Centre for Functional MRI of the Brain, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK; Department of Paediatrics, University of Oxford, Oxford, UK.
Archana Singh-ManouxINSERM U1153, Epidemiology of Ageing and Neurodegenerative Diseases, Université de Paris, Paris, France; Department of Epidemiology and Public Health, University College London, London, UK.
Mika KivimäkiDepartment of Epidemiology and Public Health, University College London, London, UK.
Klaus P EbmeierDepartment of Psychiatry, Warneford Hospital, University of Oxford, Oxford, UK.
Mark JenkinsonWellcome Centre for Integrative Neuroimaging, Oxford Centre for Functional MRI of the Brain, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
Francesco SardanelliDepartment of Biomedical Sciences for Health, Università degli Studi di Milano, Milan, Italy; Department of Radiology, IRCCS Policlinico San Donato, Milan, Italy.
Ludovica GriffantiWellcome Centre for Integrative Neuroimaging, Oxford Centre for Functional MRI of the Brain, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK; Wellcome Centre for Integrative Neuroimaging, Oxford Centre for Human Brain Activity, Department of Psychiatry, University of Oxford, Oxford, UK.
University of Oxford · GBWarneford Hospital · GBUniversity of Milan · ITInserm · FROxford Health NHS Foundation Trust · GBStanford University · USUniversity College London · GB
Funding
Education, socioeconomic status and Aging: transitions from multimorbidity to functional limitations and mortalityR01AG056477 · NIA · UNIVERSITY COLLEGE LONDON · PI KIVIMAKI, MIKA J, SINGH-MANOUX, ARCHANA · 2018 to 2022
$2.8MRole of mid- and late-life risk factors in social inequalities in Alzheimer's Disease and Related DementiasRF1AG062553 · NIA · INSERM PARIS 5 · PI KIVIMAKI, MIKA J, SINGH-MANOUX, ARCHANA · 2019 to 2019
$1.5MDepartment of HealthMedical Research Council G1001354Medical Research Council MC_EX_MR/N50192X/1Medical Research Council MR/K013351/1Medical Research Council MR/L023784/2Medical Research Council MR/M024962/1Medical Research Council S011676NIA NIH HHS R01 AG056477NIA NIH HHS RF1 AG062553Wellcome TrustWellcome Trust 203139/Z/16/ZWellcome Trust 215573/Z/19/Z
Abstract
White matter hyperintensities (WMHs) on T
Indexed as
Cognitive DysfunctionLeukoaraiosisWhite MatterAgedCognitionHumansMagnetic Resonance ImagingAgingCerebral small vessel diseasesCognitionMagnetic resonance imagingWhite matter
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.