ArticleInsights into imaging2021
Optimization of contrast medium volume for abdominal CT in oncologic patients: prospective comparison between fixed and lean body weight-adapted dosing protocols.
Article in Insights into imaging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 37 citations in OpenAlex.
- CT-based radiogenomic analysis to predict high-risk colon cancer (ATTRACT): a multicentric trial.European radiology · 2025Trial
- Lean body weight-based contrast injection protocol in liver CT: optimization of contrast medium dose.La Radiologia medica · 2025Trial
- Virtual non-contrast images from dual-layer spectral CT: comparison with true non-contrast across abdominal structures.European radiology · 2026Article
- Body composition as a predictor of cancer-related death in colon cancer: an AI-based volumetric analysis.La Radiologia medica · 2026Article
- Utilisation of Objective and Subjective Image Quality Metrics to Guide Optimal Contrast Volumes for Abdominal CT.Journal of medical radiation sciences · 2026Article
- Iodinated Contrast Media Dose Protocols for Computed Tomography Investigations of the Abdomen: A Systematic Review and Meta-Analysis.Journal of imaging · 2026Review
- Optimization of high-concentration (400 mgI/mL) contrast media volume for abdominal computed tomography: a comparison between fixed-dose and total body weight-based protocols.Quantitative imaging in medicine and surgery · 2026Article
- Virtual biopsy through CT imaging: can radiomics differentiate between subtypes of non-small cell lung cancer?La Radiologia medica · 2025Article
- Potential of photon-counting detector CT technology for contrast medium reduction in portal venous phase thoracoabdominal CT.European radiology · 2025Article
- Are we systematically overdosing women? Revisiting standardized contrast protocols for thoracoabdominal CT scans.European radiology · 2025Article
- Innovation and Optimization of Contrast Media Administration in Computed Tomography.Korean journal of radiology · 2025Article
- Feasibility of a single-phase portal venous CT protocol using bolus tracking technique and lean body weight-based contrast media dose.European radiology · 2025Article
- Radiomics in advanced gastroenteropancreatic neuroendocrine neoplasms: Identifying responders to somatostatin analogs.Journal of neuroendocrinology · 2025Article
- Low-dose liver CT: image quality and diagnostic accuracy of deep learning image reconstruction algorithm.European radiology · 2024Article
- Is CT Radiomics Superior to Morphological Evaluation for pN0 Characterization? A Pilot Study in Colon Cancer.Cancers · 2024Article
- Decreased portal vein attenuation and liver enhancement with reduced intravenous contrast dosage during the national iodinated contrast shortage of 2022.Journal of clinical imaging science · 2024Article
- The impact of body compositions on contrast medium enhancement in chest CT: a randomised controlled trial.BJR open · 2023Article
- Lean body weight-adjusted intravenous iodinated contrast dose for abdominal CT in dogs reduces interpatient enhancement variability while providing diagnostic quality organ enhancement.Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association · 2022Article
- Radiomic Cancer Hallmarks to Identify High-Risk Patients in Non-Metastatic Colon Cancer.Cancers · 2022Article
- Individualized Contrast Media Application Based on Body Weight and Contrast Enhancement in Computed Tomography of Livers without Steatosis.Diagnostics (Basel, Switzerland) · 2022Article
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Authors and funding
15 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPatient body size represents the main determinant of parenchymal enhancement and by adjusting the contrast media (CM) dose to patient weight may be a more appropriate approach to avoid a patient over dosage of CM. To compare the performance of fixed-dose and lean body weight (LBW)-adapted contrast media dosing protocols, in terms of image quality and parenchymal enhancement.
resultsOne-hundred cancer patients undergoing multiphasic abdominal CT were prospectively enrolled in this multicentric study and randomly divided in two groups: patients in fixed-dose group (n = 50) received 120 mL of CM while in LBW group (n = 50) the amount of CM was computed according to the patient's LBW. LBW protocol group received a significantly lower amount of CM (103.47 ± 17.65 mL vs. 120.00 ± 0.00 mL, p < 0.001). Arterial kidney signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) and pancreatic CNR were significantly higher in LBW group (all p ≤ 0.004). LBW group provided significantly higher arterial liver, kidney, and pancreatic contrast enhancement index (CEI) and portal venous phase kidney CEI (all p ≤ 0.002). Significantly lower portal vein SNR and CNR were observed in LBW-Group (all p ≤ 0.020).
conclusionsLBW-adapted CM administration for abdominal CT reduces the volume of injected CM and improves both image quality and parenchymal enhancement.
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