ArticleEJNMMI physics2021
Validation of CARE kV automated tube voltage selection for PET-CT: PET quantification and CT radiation dose reduction in phantoms.
Article in EJNMMI physics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7 citing papers in PubMed.
- Automated quality assurance of imaging dose and protocol adherence in computed tomography radiotherapy planning using TotalSegmentator-based segmentation.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2026Article
- [Staging and treatment response assessment with radiological and nuclear medicine approaches for non-Hodgkin lymphomas].Radiologie (Heidelberg, Germany) · 2025Review
- CT radiation dose reduction with tin filter for localisation/characterisation level image quality in PET-CT: a phantom study.EJNMMI physics · 2024Article
- EANM procedural recommendations for managing the paediatric patient in diagnostic nuclear medicine.European journal of nuclear medicine and molecular imaging · 2023Review
- The variability of CT scan protocols for total hip arthroplasty: a call for harmonisation.EFORT open reviews · 2023Review
- Ultra-low-dose CT for attenuation correction: dose savings and effect on PET quantification for protocols with and without tin filter.EJNMMI physics · 2023Article
- A survey of local diagnostic reference levels for the head, thorax, abdomen and pelvis computed tomography in Norway and Canada.Acta radiologica open · 2022Article
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Abstract
backgroundApplied tube voltage (kilovolts, kV) and tube current (milliampere seconds, mAs) affect CT radiation dose and image quality and should be optimised for the individual patient. CARE kV determines the kV and mAs providing the lowest dose to the patient, whilst maintaining user-defined reference image quality. Given that kV changes affect CT values which are used to obtain attenuation maps, the aim was to evaluate the effect of kV changes on PET quantification and CT radiation dose using phantoms.
methodFour phantoms ('Lungman', 'Lungman plus fat', 'Esser' and 'NEMA image quality' (NEMA IQ)) containing F-18 sources underwent 1 PET and 5 CT scans, with CARE kV on (automatic kV selection and mAs modulation) and in semi mode with specified tube voltages of 140, 120, 100 and 80 kV (mAs modulation only). A CARE kV image quality reference of 120 kV/50 mAs was used. Impact on PET quantification was determined by comparing measured activity concentrations for PET reconstructions from different CT scans with the reconstruction using the 120 kV reference, and dose (DLP, CTDI
resultsCARE kV-determined optimal tube voltage and CARE kV 'on' dose (DLP) savings compared with the 120 kV reference were: Lungman, 100 kV, 2.0%; Lungman plus fat, 120 kV, 0%; Esser, 100 kV, 9.3%; NEMA IQ, 100 kV, 3.4%. Using tube voltages in CARE kV 'semi' mode which were not advised by CARE kV 'on' resulted in dose increases ≤ 65% compared with the 120 kV reference (greatest difference Lungman plus fat, 80 kV). Clinically insignificant differences in PET activity quantification of up to 0.7% (Lungman, 100 kV, mean measured activity concentration) were observed when using the optimal tube voltage advised by CARE kV. Differences in PET quantification of up to 4.0% (Lungman, 140 kV, maximum measured activity concentration) were found over the full selection of tube voltages in semi mode, with the greatest differences seen at the most suboptimal kV for each phantom. However, most differences were within 1%.
conclusionsCARE kV on can provide CT radiation dose savings without concern over changes in PET quantification.
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