Evidence map›Paper›PMID 33743083›Full record

ArticleActa diabetologica2021

Carotid intima-media thickness and arterial stiffness in relation to cerebral small vessel disease in neurologically asymptomatic individuals with type 1 diabetes.

Jussi Inkeri, Anniina Tynjälä, Carol Forsblom, Ron Liebkind, Turgut Tatlisumak, Lena M Thorn, Per-Henrik Groop, Sara Shams, Jukka Putaala, Juha Martola and 2 more

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In one paragraph

Article in Acta diabetologica, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 4 pooled it
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 4 syntheses or guidelines pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Association between pulse wave velocity and cerebral microbleeds: a systematic review and meta-analysis.Hypertension research : official journal of the Japanese Society of Hypertension · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 4 countries.

Jussi InkeriHUS Medical Imaging Center, Radiology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Anniina TynjäläFolkhälsan Institute of Genetics, Folkhälsan Research Center, Helsinki, Finland.
Carol ForsblomFolkhälsan Institute of Genetics, Folkhälsan Research Center, Helsinki, Finland.
Ron LiebkindNeurology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Turgut TatlisumakNeurology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Lena M ThornFolkhälsan Institute of Genetics, Folkhälsan Research Center, Helsinki, Finland.
Per-Henrik GroopFolkhälsan Institute of Genetics, Folkhälsan Research Center, Helsinki, Finland. per-henrik.groop@helsinki.fi.ORCID http://orcid.org/0000-0003-4055-6954
Sara ShamsDepartment of Radiology, Karolinska University Hospital, Stockholm, Sweden.
Jukka PutaalaNeurology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Juha MartolaHUS Medical Imaging Center, Radiology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Daniel GordinFolkhälsan Institute of Genetics, Folkhälsan Research Center, Helsinki, Finland.
FinnDiane Study Group
University of Helsinki · FIJoslin Diabetes Center · USKarolinska University Hospital · SE

Funding

Academy of Finland 316664Academy of Finland UAK10121MRINovo Nordisk Foundation NNF OC0013657
6 · The paper itself

Abstract

aimsTo determine if arterial functional and structural changes are associated with underlying cerebral small vessel disease in neurologically asymptomatic individuals with type 1 diabetes.

methodsWe enrolled 186 individuals (47.8% men; median age 40.0, IQR 33.0-45.0 years) with type 1 diabetes (median diabetes duration of 21.6, IQR 18.2-30.3 years), and 30 age- and sex-matched healthy controls, as part of the Finnish Diabetic Nephropathy (FinnDiane) Study. All individuals underwent a biochemical work-up, brain magnetic resonance imaging (MRI), ultrasound of the common carotid arteries and arterial tonometry. Arterial structural and functional parameters were assessed by carotid intima-media thickness (CIMT), pulse wave velocity and augmentation index.

resultsCerebral microbleeds (CMBs) were present in 23.7% and white matter hyperintensities (WMHs) in 16.7% of individuals with type 1 diabetes. Those with type 1 diabetes and CMBs had higher median (IQR) CIMT 583 (525 - 663) μm than those without 556 (502 - 607) μm, p = 0.016). Higher CIMT was associated with the presence of CMBs (p = 0.046) independent of age, eGFR, ApoB, systolic blood pressure, albuminuria, history of retinal photocoagulation and HbA

conclusionsStructural, but not functional, arterial changes are associated with underlying CMBs in asymptomatic individuals with type 1 diabetes.

Indexed as

Carotid Intima-Media ThicknessVascular StiffnessAdultAsymptomatic DiseasesBlood PressureCarotid ArteriesCase-Control StudiesCerebral Small Vessel DiseasesDiabetes Mellitus, Type 1Diabetic AngiopathiesFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedPulse Wave AnalysisArterial tonometryCarotid intima-media thicknessCerebral microbleedMagnetic resonance imaging

Identifiers

PMID33743083
PMCPMC8187193
OpenAlexW3136957260

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.