Evidence map›Paper›PMID 33743059›Full record

Trial reportWorld journal of urology2021

Urinary continence recovery and oncological outcomes after surgery for prostate cancer analysed by risk category: results from the LAParoscopic prostatectomy robot and open trial.

Anna Hagman, Anna Lantz, Stefan Carlsson, Jonas Höijer, Johan Stranne, S I Tyritzis, Eva Haglind, Anders Bjartell, Jonas Hugosson, Olof Akre and 2 more

Abstract readClinical TrialComparative StudyMulticenter Study
PubMed Publisher
In one paragraph

Trial report in World journal of urology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 2 countries.

Anna HagmanDepartment of Molecular Medicine, Surgery and Pelvic Cancer, Karolinska Institutet, Karolinska University Hospital, 17176, Stockholm, Sweden. anna.m.hagman@sll.se.ORCID http://orcid.org/0000-0002-6755-2112
Anna LantzDepartment of Molecular Medicine, Surgery and Pelvic Cancer, Karolinska Institutet, Karolinska University Hospital, 17176, Stockholm, Sweden.
Stefan CarlssonDepartment of Molecular Medicine, Surgery and Pelvic Cancer, Karolinska Institutet, Karolinska University Hospital, 17176, Stockholm, Sweden.
Jonas HöijerDepartment of Surgical Sciences, Uppsala University, Uppsala, Sweden.
Johan StranneDepartment of Urology, Institute of Clinical Science, Sahlgrenska Academy At the University of Gothenburg, Gothenburg, Sweden.
S I TyritzisDepartment of Molecular Medicine, Surgery and Pelvic Cancer, Karolinska Institutet, Karolinska University Hospital, 17176, Stockholm, Sweden.
Eva HaglindDepartment of Surgery, Institute of Clinical Sciences, Sahlgrenska Academy At the University of Gothenburg, Scandinavian Surgical Outcomes Research Group, Gothenburg, Sweden.
Anders BjartellDepartment of Urology, Skåne University Hospital, Lund University, Lund, Sweden.
Jonas HugossonDepartment of Urology, Institute of Clinical Science, Sahlgrenska Academy At the University of Gothenburg, Gothenburg, Sweden.
Olof AkreDepartment of Molecular Medicine, Surgery and Pelvic Cancer, Karolinska Institutet, Karolinska University Hospital, 17176, Stockholm, Sweden.
Gunnar SteineckDivision of Clinical Cancer Epidemiology, Department of Oncology, Institute of Clinical Sciences, Sahlgrenska Academy At the University of Gothenburg, Gothenburg, Sweden.
Peter WiklundDepartment of Molecular Medicine, Surgery and Pelvic Cancer, Karolinska Institutet, Karolinska University Hospital, 17176, Stockholm, Sweden.
Karolinska University Hospital · SESahlgrenska University Hospital · SEKarolinska Institutet · SELund University · SEMount Sinai Health System · USUniversity of Gothenburg · SEUppsala University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo evaluate urinary continence (UC) recovery and oncological outcomes in different risk-groups after robot-assisted radical prostatectomy (RALP) and open retropubic radical prostatectomy (RRP). PATIENTS AND

methodsWe analysed 2650 men with prostate cancer from seven open (n = 805) and seven robotic (n = 1845) Swedish centres between 2008 and 2011 in a prospective non-randomised trial, LAPPRO. UC recovery was defined as change of pads less than once in 24 h. Information was collected through validated questionnaires. Rate of positive surgical margins (PSM) and biochemical recurrence (BCR), defined as prostate-specific antigen (PSA) > 0.25 mg/ml, were recorded. We stratified patients into two risk groups (low-intermediate and high risk) based on the D'Amico risk classification system.

resultAmong men with high-risk prostate cancer, we found significantly higher rates of UC recovery up to 24 months after RRP compared to RALP (66.1% vs 60.5%) RR 0.85 (CI 95% 0.73-0.99) while PSM was more frequent after RRP compared to RALP (46.8% vs 23.5%) RR 1.56 (CI 95% 1.10-2.21). In the same group no significant difference was seen in BCR. Overall, however, BCR was significantly more common after RRP compared to RALP at 24 months (9.8% vs 6.6%) RR 1.43 (Cl 95% 1.08-1.89). The limitations of this study are its non-randomized design and the relatively short time of follow-up.

conclusionsOur study indicates that men with high-risk tumour operated with open surgery had better urinary continence recovery but with a higher risk of PSM than after robotic-assisted laparoscopic surgery. No significant difference was seen in biochemical recurrence. 

trial registrationISRCTN06393679.

Indexed as

LaparoscopyRecovery of FunctionRobotic Surgical ProceduresUrinationAdultAgedHumansMaleMiddle AgedProspective StudiesProstatectomyProstatic NeoplasmsRisk AssessmentSwedenTreatment OutcomeProstate cancerProstatectomyRecurrenceRobot-assisted surgeryUrinary incontinence

Identifiers

PMID33743059
OpenAlexW3137840505

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.