ArticleJournal of diabetes investigation2021
Midlife and late-life diabetes and sarcopenia in a general older Japanese population: The Hisayama Study.
Article in Journal of diabetes investigation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.
- Prevalence and risk factors of sarcopenia in Asian adults with type 2 diabetes: A systematic review and meta-analysis.Journal of diabetes investigation · 2026Pooled it
- Metabolic-inflammatory axis linking diabetes and sarcopenia: cross-population evidence and explainable ai-based risk modeling.Acta diabetologica · 2026Article
- Phase angle, extracellular to intracellular water ratio, and advanced glycation end products according to four sarcopenia categories and in relation to muscle strength/mass in elderly out-patients with diabetes.Diabetology international · 2026Article
- Health checkup profile before age 65 and long-term care needs: a retrospective analysis of the Fukuoka-City Information Platform for Community-based Integrated Care.Environmental health and preventive medicine · 2026Article
- Associations between upper limb flexibility and all-cause mortality in the oldest-old.Journal of global health · 2025Article
- Association of kidney function with physical performance: the Maastricht study.Journal of nephrology · 2024Article
- Type 2 Diabetes Mellitus and Sarcopenia as Comorbid Chronic Diseases in Older Adults: Established and Emerging Treatments and Therapies.Diabetes & metabolism journal · 2023Review
- Effects of exercise habits in adolescence and older age on sarcopenia risk in older adults: the Bunkyo Health Study.Journal of cachexia, sarcopenia and muscle · 2023Article
- Effect of sarcopenia, osteoporosis, and osteosarcopenia on spine fracture in American adults with prediabetes.Frontiers in endocrinology · 2023Article
- Prediabetes is an independent risk factor for sarcopenia in older men, but not in older women: the Bunkyo Health Study.Journal of cachexia, sarcopenia and muscle · 2022Article
- Sarcopenia in elderly diabetes.Journal of diabetes investigation · 2022Article
- Midlife and late-life diabetes and sarcopenia in a general older Japanese population: The Hisayama Study.Journal of diabetes investigation · 2021Article
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Authors and funding
13 authors at 1 institution in 1 country.
Funding
Abstract
AIMS/
introductionTo investigate the association between midlife or late-life diabetes and the development of sarcopenia in an older Japanese population. MATERIALS AND
methodsA total of 824 Japanese residents aged 65 to 84 years without sarcopenia were followed up from 2012 to 2017. Sarcopenia was determined following the Asian Working Group for Sarcopenia definition. The time of diabetes diagnosis was classified as midlife or late-life diabetes by the age at first diagnosis of diabetes (< 65 or ≥ 65 years) based on annual health checkups data over the past 24 years. The duration of diabetes was categorized into three groups of < 10, 10-15, and > 15 years. The odds ratios of incident sarcopenia according to the diabetic status were estimated using a logistic regression analysis.
resultsDuring follow-up, 47 subjects developed sarcopenia. The multivariable-adjusted odds ratio for incident sarcopenia was significantly greater in subjects with diabetes at baseline than in those without it (odds ratio 2.51, 95% confidence interval 1.26-5.00). Subjects with midlife diabetes had a significantly greater risk of incident sarcopenia, whereas no significant association between late-life diabetes and incident sarcopenia was observed. With a longer duration of diabetes, the risk of incident sarcopenia increased significantly (P for trend = 0.002).
conclusionsThe present study suggests that midlife diabetes and a longer duration of diabetes are significant risk factors for incident sarcopenia in the older population. Preventing diabetes in midlife may reduce the risk of the development of sarcopenia in later life.
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