ArticleMolecular plant pathology2021
A haustorial-expressed lytic polysaccharide monooxygenase from the cucurbit powdery mildew pathogen Podosphaera xanthii contributes to the suppression of chitin-triggered immunity.
Article in Molecular plant pathology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Structure-Based Comparative Analysis Reveals the Landscape of Powdery Mildew Secretomes Across Five Genera.Pathogens (Basel, Switzerland) · 2026Article
- Stagonosporopsis cucurbitacearum Effector Protein ScAA9 Contributes to Virulence and Triggers Plant Immune Responses.Molecular plant pathology · 2026Article
- Plant cell walls as a key driver of plant-pathogen coevolution.FEMS microbiology reviews · 2026Review
- Article
- AI-Integrated Omics Analysis Reveals Cultivar-Specific Resistance Mechanisms to Powdery Mildew inInternational journal of molecular sciences · 2025Article
- 'Bioinspired nano-architected chitosan-β-glucan nanocomposite as an elicitor for disease management sustainably'.Scientific reports · 2025Article
- Genomic and Functional Analysis of Auxiliary Activity Enzymes in the Maize Anthracnose PathogenMicroorganisms · 2025Article
- Explorations of a novel effector CcAA9-20333 from Colletotrichum coccodes: the potential roles played in host immunity.Plant cell reports · 2025Article
- Article
- Comparative secretome analysis unveils species-specific virulence factors inAIMS microbiology · 2024Article
- Suppression of Chitin-Triggered Immunity by Plant Fungal Pathogens: A Case Study of the Cucurbit Powdery Mildew FungusJournal of fungi (Basel, Switzerland) · 2023Review
- Lessons on fruiting body morphogenesis from genomes and transcriptomes ofStudies in mycology · 2023Article
- RNAi Technology: A New Path for the Research and Management of Obligate Biotrophic Phytopathogenic Fungi.International journal of molecular sciences · 2023Review
- A fungal lytic polysaccharide monooxygenase is required for cell wall integrity, thermotolerance, and virulence of the fungal human pathogen Cryptococcus neoformans.PLoS pathogens · 2023Article
- In Silico Characterization of the Secretome of the Fungal PathogenJournal of fungi (Basel, Switzerland) · 2023Article
- Plant Cell Wall Integrity Perturbations and Priming for Defense.Plants (Basel, Switzerland) · 2022Review
- Rational Design of Chitin Deacetylase Inhibitors for Sustainable Agricultural Use Based on Molecular Topology.Journal of agricultural and food chemistry · 2022Article
- Suppression of Chitin-Triggered Immunity by a New Fungal Chitin-Binding Effector Resulting from Alternative Splicing of a Chitin Deacetylase Gene.Journal of fungi (Basel, Switzerland) · 2022Article
- Deletion of AA9 Lytic Polysaccharide Monooxygenases Impacts A. nidulans Secretome and Growth on Lignocellulose.Microbiology spectrum · 2022Article
- Chitin Deacetylase, a Novel Target for the Design of Agricultural Fungicides.Journal of fungi (Basel, Switzerland) · 2021Article
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4 authors.
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Abstract
Podosphaera xanthii is the main causal agent of cucurbit powdery mildew and a limiting factor of crop productivity. The lifestyle of this fungus is determined by the development of specialized parasitic structures inside epidermal cells, termed haustoria, that are responsible for the acquisition of nutrients and the release of effectors. A typical function of fungal effectors is the manipulation of host immunity, for example the suppression of pathogen-associated molecular pattern (PAMP)-triggered immunity (PTI). Chitin is a major component of fungal cell walls, and chitin oligosaccharides are well-known PAMP elicitors. In this work, we examined the role of PHEC27213, the most highly expressed, haustorium-specific effector candidate of P. xanthii. According to different computational predictions, the protein folding of PHEC27213 was similar to that of lytic polysaccharide monooxygenases (LPMOs) and included a conserved histidine brace; however, PHEC27213 had low sequence similarity with LPMO proteins and displayed a putative chitin-binding domain that was different from the canonical carbohydrate-binding module. Binding and enzymatic assays demonstrated that PHEC27213 was able to bind and catalyse colloidal chitin, as well as chitooligosaccharides, acting as an LPMO. Furthermore, RNAi silencing experiments showed the potential of this protein to prevent the activation of chitin-triggered immunity. Moreover, proteins with similar features were found in other haustorium-forming fungal pathogens. Our results suggest that this protein is a new fungal LPMO that catalyses chitooligosaccharides, thus contributing to the suppression of plant immunity during haustorium development. To our knowledge, this is the first mechanism identified in the haustorium to suppress chitin signalling.
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