ArticleActa paediatrica (Oslo, Norway : 1992)2021
High rates of antibiotic prescriptions in children with COVID-19 or multisystem inflammatory syndrome: A multinational experience in 990 cases from Latin America.
Article in Acta paediatrica (Oslo, Norway : 1992), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 43 citations in OpenAlex.
- The impact of immunocompromise on outcomes of COVID-19 in children and young people-a systematic review and meta-analysis.Frontiers in immunology · 2023Pooled it
- Pooled it
- Antibiotic overuse in children with viral infections: lessons from the SARS-CoV-2 pandemic.BMJ paediatrics open · 2026Article
- Impact of COVID-19 on Antimicrobial Stewardship Activities in Hospitalised Children: A Scoping Review.Journal of paediatrics and child health · 2025Article
- Multisystem inflammatory syndrome in children (MIS-C) and sepsis differentiation by a clinical and analytical score: MISSEP score.European journal of pediatrics · 2023Article
- The Impact of the COVID-19 Pandemic on Antimicrobial Resistance and Management of Bloodstream Infections.Pathogens (Basel, Switzerland) · 2023Article
- Regional Perspective of Antimicrobial Stewardship Programs in Latin American Pediatric Emergency Departments.Antibiotics (Basel, Switzerland) · 2023Review
- Antibiotic Overprescribing among Neonates and Children Hospitalized with COVID-19 in Pakistan and the Implications.Antibiotics (Basel, Switzerland) · 2023Article
- Community-Onset Bacterial Coinfection in Children Critically Ill With Severe Acute Respiratory Syndrome Coronavirus 2 Infection.Open forum infectious diseases · 2023Article
- COVID-19 in Latin America: A Snapshot in Time and the Road Ahead.Infectious diseases and therapy · 2023Review
- Factors Associated with the Antibiotic Treatment of Children Hospitalized for COVID-19 during the Lockdown in Serbia.International journal of environmental research and public health · 2022Article
- Increased Detection of Carbapenemase-Producing Enterobacterales Bacteria in Latin America and the Caribbean during the COVID-19 Pandemic.Emerging infectious diseases · 2022Article
- Use of broad-spectrum antibiotics in children diagnosed with multisystem inflammatory syndrome temporarily associated with SARS-CoV-2 infection in Poland: the MOIS-CoR study.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2022Article
- Antibiotic use in children with multisystem inflammatory syndrome associated with SARS-CoV-2.Acta paediatrica (Oslo, Norway : 1992) · 2022Article
- Decreased survival in children inpatients with COVID-19 and antibiotic prescription.BMC infectious diseases · 2022Article
- COVID-19 in a tertiary paediatric centre in Portugal: a single-centre retrospective study.BMJ paediatrics open · 2022Article
- Vaccination of children against COVID-19: the experience in Latin America.Annals of clinical microbiology and antimicrobials · 2022Article
- Association between Coagulation Profile and Clinical Outcome in Children with SARS-CoV-2 Infection or MIS-C: A Multicenter Cross-Sectional Study.Children (Basel, Switzerland) · 2022Article
- Correlation of SARS-CoV-2 Viral Load and Clinical Evolution of Pediatric Patients in a General Hospital From Buenos Aires, Argentina.Frontiers in pediatrics · 2022Article
- Multisystem Inflammatory Syndrome Temporally Related to COVID-19 in Children From Latin America and the Caribbean Region: A Systematic Review With a Meta-Analysis of Data From Regional Surveillance Systems.Frontiers in pediatrics · 2022Review
Corrections and comments
- Commented on by
Authors and funding
14 authors at 8 institutions in 6 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimThis study aims to assess rates of antibiotic prescriptions and its determinants in in children with COVID-19 or Multisystem Inflammatory Syndrome (MIS-C).
methodsChildren <18 years-old assessed in five Latin Americas countries with a diagnosis of COVID-19 or MIS-C were enrolled. Antibiotic prescriptions and factors associated with their use were assessed.
resultsA total of 990 children were included: 921 (93%) with COVID-19, 69 (7.0%) with MIS-C. The prevalence of antibiotic use was 24.5% (n = 243). MIS-C with (OR = 45.48) or without (OR = 10.35) cardiac involvement, provision of intensive care (OR = 9.60), need for hospital care (OR = 6.87), pneumonia and/or ARDS detected through chest X-rays (OR = 4.40), administration of systemic corticosteroids (OR = 4.39), oxygen support, mechanical ventilation or CPAP (OR = 2.21), pyrexia (OR = 1.84), and female sex (OR = 1.50) were independently associated with increased use of antibiotics. There was significant variation in antibiotic use across the hospitals.
conclusionOur study showed a high rate of antibiotic prescriptions in children with COVID-19, in particular in those with severe disease or MIS-C. Prospective studies are needed to provide better evidence on the recognition and management of bacterial infections in COVID-19 children.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.