Evidence map›Paper›PMID 33742457›Full record

ArticlePediatric dermatology2021

Acral Changes in pediatric patients during COVID 19 pandemic: Registry report from the COVID 19 response task force of the society of pediatric dermatology (SPD) and pediatric dermatology research alliance (PeDRA).

Leslie Castelo-Soccio, Irene Lara-Corrales, Amy S Paller, Eric Bean, Sneha Rangu, Michelle Oboite, Carsten Flohr, Regina-Celeste Ahmad, Valerie Calberg, Amy Gilliam and 8 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric dermatology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 8 institutions in 3 countries.

Leslie Castelo-SoccioDepartment of Pediatrics, Section of Dermatology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.ORCID https://orcid.org/0000-0003-3289-446X
Irene Lara-CorralesSection of Dermatology, Division of Pediatric Medicine, University of Toronto, The Hospital for Sick Children, Toronto, ON, Canada.
Amy S PallerDepartments of Dermatology and Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Eric BeanPerelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Sneha RanguDepartment of Pediatrics, Section of Dermatology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Michelle OboiteDepartment of Pediatrics, Section of Dermatology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Carsten FlohrSt. John's Institute of Dermatology, King's College London, London, UK.
Regina-Celeste AhmadDepartment of Dermatology, University of California San Francisco, San Francisco, CA, USA.
Valerie CalbergDepartment of Dermatology, Medical College of Wisconsin, Milwaukee, WI, USA.
Amy GilliamDepartment of Dermatology, University of California San Francisco, San Francisco, CA, USA.
Elena PopeSection of Dermatology, Division of Pediatric Medicine, University of Toronto, The Hospital for Sick Children, Toronto, ON, Canada.ORCID https://orcid.org/0000-0002-2136-5661
Sean ReynoldsDepartment of Dermatology, University of California San Francisco, San Francisco, CA, USA.
Cathryn SibbaldSection of Dermatology, Division of Pediatric Medicine, University of Toronto, The Hospital for Sick Children, Toronto, ON, Canada.ORCID https://orcid.org/0000-0001-9288-1121
Helen T ShinDepartment of Dermatology, Pediatric Dermatology, The Joseph M. Sanzari Children's Hospital at Hackensack University Medical Center and Hackensack Meridian School of Medicine, Hackensack, NJ, USA.
Emily BergerDepartment of Dermatology, Pediatric Dermatology, The Joseph M. Sanzari Children's Hospital at Hackensack University Medical Center and Hackensack Meridian School of Medicine, Hackensack, NJ, USA.
Julie SchafferDepartment of Dermatology, Pediatric Dermatology, The Joseph M. Sanzari Children's Hospital at Hackensack University Medical Center and Hackensack Meridian School of Medicine, Hackensack, NJ, USA.
Michael P SiegelPediatric Dermatology Research Alliance, Indianapolis, IN, USA.
Kelly M CordoroDepartment of Dermatology, University of California San Francisco, San Francisco, CA, USA.
University of California, San Francisco · USChildren's Hospital of Philadelphia · USHackensack University Medical Center · USUniversity of Toronto · CAKing's College London · GBMedical College of Wisconsin · USNorthwestern University · USUniversity of Pennsylvania · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

objectiveIn spring 2020, high numbers of children presented with acral pernio-like skin rashes, concurrent with the coronavirus disease 2019 (COVID-19) pandemic. Understanding their clinical characteristics/ infection status may provide prognostic information and facilitate decisions about management.

methodsA pediatric-specific dermatology registry was created by the Pediatric Dermatology COVID-19 Response Task Force of the Society for Pediatric Dermatology (SPD) and Pediatric Dermatology Research Alliance (PeDRA) and was managed by Children's Hospital of Philadelphia using REDCap.

resultsData from 378 children 0-18 years entered into the registry between April 13 and July 17, 2020 were analyzed. Data were drawn from a standardized questionnaire completed by clinicians which asked for demographics, description of acral lesions, symptoms before and after acral changes, COVID-19 positive contacts, treatment, duration of skin changes, laboratory testing including SARS-CoV-2 PCR and antibody testing, as well as histopathology. 229 (60.6%) were male with mean age of 13.0 years (± 3.6 years). Six (1.6%) tested positive for SARS-CoV-2. Pedal lesions (often with pruritus and/or pain) were present in 96%. 30% (114/378) had COVID-19 symptoms during the 30 days prior to presentation. Most (69%) had no other symptoms and an uneventful course with complete recovery. CONCLUSIONS AND RELEVANCE: Children with acral pernio-like changes were healthy and all recovered with no short-term sequelae. We believe these acral changes are not just a temporal epiphenomenon of shelter in place during the spring months of the first wave of the COVID-19 pandemic and may be a late phase reaction that needs further study.

Indexed as

COVID-19AdolescentChildDermatologyHumansMalePandemicsPediatricsPhiladelphiaRegistriesSkin Diseasesexanthemsinfection-viralskin signs of systemic disease

Identifiers

PMID33742457
PMCPMC8250200
OpenAlexW3137385422

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.