Evidence map›Paper›PMID 33742354›Full record

SynthesisNeuropsychology review2021

Antisaccades in Parkinson's Disease: A Meta-Analysis.

Josefine Waldthaler, Lena Stock, Justus Student, Johanna Sommerkorn, Stefan Dowiasch, Lars Timmermann

Registry-linked trialAbstract readMeta-AnalysisReview
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Neuropsychology review, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06899022 (Investigating the Role of Attention in Perceptual and Cognitive Consequences of Parkinson's Disease), which is not on this map. Cited by 33 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06899022 narecruitingnot on this mapstarted 2025, after this paper: background citation

Investigating the Role of Attention in Perceptual and Cognitive Consequences of Parkinson's Disease

TypeinterventionalSponsorUniversity of NebraskaRan2025 to 2028Enrolled138ConditionsEssential Tremor, Parkinson&#39, s Disease (PD), DystoniasArmsNormal therapeutic DBS, Reduced current DBS, Reduced frequency DBS
3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
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  13. An Evaluation of Test-Retest Reliability of the Saccadometry Test.Journal of the American Academy of Audiology · 2025
    Article
  14. Review
  15. Article
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  18. Eyes as a window to brain pathology in parkinson's disease: a narrative review.Journal of neural transmission (Vienna, Austria : 1996) · 2024
    Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Josefine WaldthalerDepartment of Neurology, University Hospital Marburg, 35033, Marburg, Germany. josefine.waldthaler@staff.uni-marburg.de.ORCID 0000-0002-6505-9922
Lena StockDepartment of Neurology, University Hospital Marburg, 35033, Marburg, Germany.
Justus StudentDepartment of Neurology, University Hospital Marburg, 35033, Marburg, Germany.
Johanna SommerkornDepartment of Neurology, University Hospital Marburg, 35033, Marburg, Germany.
Stefan DowiaschCMBB - Center for Mind, Brain and Behavior, Universities Gießen and Marburg, Marburg, Germany.
Lars TimmermannDepartment of Neurology, University Hospital Marburg, 35033, Marburg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The usefulness of eye-tracking tasks as potential biomarkers for motor or cognitive disease burden in Parkinson's disease (PD) has been subject of debate for many years. Several studies suggest that the performance in the antisaccade task may be altered in patients with PD and associated with motor disease severity or executive dysfunction. In this meta-analysis, random effects models were used to synthesize the existing evidence on antisaccade error rates and latency in PD. Furthermore, meta-regressions were performed to assess the role of motor and cognitive disease severity, dopaminergic medication and methodological factors. Additionally, the impact of acute levodopa administration and activation of deep brain stimulation was evaluated in two separate sub-analyses.This meta-analysis confirms that antisaccade latency and error rate are significantly increased in PD. Disease duration, Unified Parkinson's disease rating scale score and Hoehn and Yahr stage mediate the effect of PD on antisaccade latency with higher motor burden being associated with increased antisaccade latency.Acute administration of levodopa had no significant effects on antisaccade performance in a small number of eligible studies. Deep brain stimulation in the subthalamic nucleus, on the other hand, may alter the speed accuracy trade-off supporting an increase of impulsivity following deep brain stimulation in PD.According to the results of the meta-analysis, antisaccade latency may provide a potential marker for disease severity and progression in PD which needs further confirmation in longitudinal studies.

Indexed as

Cognition DisordersDeep Brain StimulationParkinson DiseaseSubthalamic NucleusHumansLevodopaLevodopaAntisaccadeExecutive functionsEye movementEye-trackingParkinson’s diseaseSaccade

Identifiers

PMID33742354
PMCPMC8592977

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.