ArticleCommunications biology2021
The structure of a major surface antigen SAG19 from Eimeria tenella unifies the Eimeria SAG family.
Article in Communications biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 16 citations in OpenAlex.
- Integrative comparative genomics and transcriptomics reveal key roles of SAG17 and SAG23 in early-stage virulence divergence of Eimeria tenella.Veterinary research · 2026Article
- Molecular characterization of Eimeria necatrix surface antigen SAG8 and SAG36 genes and their immunoprotective efficacy in chicken.BMC veterinary research · 2026Article
- Antithrombotic Function of Dahuang Zhechong Pill and Its Active Ingredients: A Review.Chinese journal of integrative medicine · 2026Review
- Insights into genomic sequence diversity of the SAG surface antigen superfamily in geographically diverse Eimeria tenella isolates.Scientific reports · 2024Article
- RNA-Seq of Phenotypically DistinctPathogens (Basel, Switzerland) · 2023Article
- Proteomic Analysis of FractionatedInternational journal of molecular sciences · 2023Article
- What Do We Know about Surface Proteins of Chicken ParasitesLife (Basel, Switzerland) · 2023Review
- Prokaryotic Expression ofInternational journal of molecular sciences · 2022Article
- Eimeria proteins: order amidst disorder.Parasites & vectors · 2022Review
- Do All Coccidia Follow the Same Trafficking Rules?Life (Basel, Switzerland) · 2021Review
- Dynamically expressed genes provide candidate viability biomarkers in a model coccidian.PloS one · 2021Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In infections by apicomplexan parasites including Plasmodium, Toxoplasma gondii, and Eimeria, host interactions are mediated by proteins including families of membrane-anchored cysteine-rich surface antigens (SAGs) and SAG-related sequences (SRS). Eimeria tenella causes caecal coccidiosis in chickens and has a SAG family with over 80 members making up 1% of the proteome. We have solved the structure of a representative E. tenella SAG, EtSAG19, revealing that, despite a low level of sequence similarity, the entire Eimeria SAG family is unified by its three-layer αβα fold which is related to that of the CAP superfamily. Furthermore, sequence comparisons show that the Eimeria SAG fold is conserved in surface antigens of the human coccidial parasite Cyclospora cayetanensis but this fold is unrelated to that of the SAGs/SRS proteins expressed in other apicomplexans including Plasmodium species and the cyst-forming coccidia Toxoplasma gondii, Neospora caninum and Besnoitia besnoiti. However, despite having very different structures, Consurf analysis showed that Eimeria SAG and Toxoplasma SRS families each exhibit marked hotspots of sequence hypervariability that map to their surfaces distal to the membrane anchor. This suggests that the primary and convergent purpose of the different structures is to provide a platform onto which sequence variability can be imposed.
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