ArticleCommunications biology2021
Evolutionary histories and antimicrobial resistance in Shigella flexneri and Shigella sonnei in Southeast Asia.
Article in Communications biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Review
- A public resource of 15 genomically characterized representative strains ofMicrobial genomics · 2026Article
- Multidrug-resistant Shigella flexneri outbreak affecting humans and non-human primates in New Mexico, USA.Nature communications · 2025Article
- Molecular epidemiology of a multidrug-resistantMicrobial genomics · 2025Article
- Phytochemical Analysis and Antimicrobial Activity ofMicroorganisms · 2024Article
- Prevalence of plasmid-mediated quinolone resistance genes and biofilm formation in different species of quinolone-resistant clinical Shigella isolates: a cross-sectional study.European journal of medical research · 2024Article
- Article
- Article
- Article
- Review
- The genomic epidemiology of shigellosis in South Africa.Nature communications · 2023Article
- Trends in antimicrobial resistance ofJAC-antimicrobial resistance · 2023Article
- Characterization of Shigella flexneri Serotype 6 Strains Isolated from Bangladesh and Identification of a New Phylogenetic Cluster.Journal of bacteriology · 2023Article
- Characterization ofAccess microbiology · 2023Article
- Prevalence of Multidrug-Resistant and Extended-Spectrum Beta-Lactamase-ProducingAntibiotics (Basel, Switzerland) · 2022Review
- Functional Role of YnfA, an Efflux Transporter in Resistance to Antimicrobial Agents in Shigella flexneri.Antimicrobial agents and chemotherapy · 2022Article
- Maintenance of the Shigella sonnei Virulence Plasmid Is Dependent on Its Repertoire and Amino Acid Sequence of Toxin-Antitoxin Systems.Journal of bacteriology · 2022Article
- Clonal serotype 1c multidrug-resistantFrontiers in medicine · 2022Article
- The evolutionary history ofMicrobial genomics · 2021Article
- Antimicrobial Resistance Dynamics in ChileanFrontiers in microbiology · 2021Article
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Authors and funding
16 authors.
Funding
Abstract
Conventional disease surveillance for shigellosis in developing country settings relies on serotyping and low-resolution molecular typing, which fails to contextualise the evolutionary history of the genus. Here, we interrogated a collection of 1,804 Shigella whole genome sequences from organisms isolated in four continental Southeast Asian countries (Thailand, Vietnam, Laos, and Cambodia) over three decades to characterise the evolution of both S. flexneri and S. sonnei. We show that S. sonnei and each major S. flexneri serotype are comprised of genetically diverse populations, the majority of which were likely introduced into Southeast Asia in the 1970s-1990s. Intranational and regional dissemination allowed widespread propagation of both species across the region. Our data indicate that the epidemiology of S. sonnei and the major S. flexneri serotypes were characterised by frequent clonal replacement events, coinciding with changing susceptibility patterns against contemporaneous antimicrobials. We conclude that adaptation to antimicrobial pressure was pivotal to the recent evolutionary trajectory of Shigella in Southeast Asia.
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