Evidence map›Paper›PMID 33742106›Full record

ArticleCommunications biology2021

Cancer genome datamining and functional genetic analysis implicate mechanisms of ATM/ATR dysfunction underpinning carcinogenesis.

Erik Waskiewicz, Michalis Vasiliou, Isaac Corcoles-Saez, Rita S Cha

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. DNA Damage and Replication Stress Checkpoints.Annual review of biochemistry · 2025
    Review
  3. Article
  4. Review
  5. Similar genetic profile in early and late stage urothelial tract cancer.Journal of cancer research and clinical oncology · 2024
    Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Erik WaskiewiczSchool of Medical Sciences and North West Cancer Research Institute, Bangor University, Bangor, UK.
Michalis VasiliouSchool of Medical Sciences and North West Cancer Research Institute, Bangor University, Bangor, UK.
Isaac Corcoles-SaezSchool of Medical Sciences and North West Cancer Research Institute, Bangor University, Bangor, UK.
Rita S ChaSchool of Medical Sciences and North West Cancer Research Institute, Bangor University, Bangor, UK. r.cha@bangor.ac.uk.ORCID 0000-0001-8223-1520
Bangor University · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

ATM and ATR are conserved regulators of the DNA damage response linked to cancer. Comprehensive DNA sequencing efforts identified ~4,000 cancer-associated mutations in ATM/ATR; however, their cancer implications remain largely unknown. To gain insights, we identify functionally important conserved residues in ATM, ATR and budding yeast Mec1

Indexed as

Data MiningMutation, MissenseAmino Acid SequenceAtaxia Telangiectasia Mutated ProteinsCell Transformation, NeoplasticConserved SequenceDatabases, GeneticEvolution, MolecularGenetic Predisposition to DiseaseGenome, HumanHumansIntracellular Signaling Peptides and ProteinsModels, MolecularNeoplasmsProtein Serine-Threonine KinasesSaccharomyces cerevisiaeAtaxia Telangiectasia Mutated ProteinsATM protein, humanATR protein, humanIntracellular Signaling Peptides and ProteinsMEC1 protein, S cerevisiaeProtein Serine-Threonine KinasesSaccharomyces cerevisiae Proteins

Identifiers

PMID33742106
PMCPMC7979806
OpenAlexW3139356243

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.