Evidence map›Paper›PMID 33742073›Full record

ArticleScientific reports2021

Association between smoking status and outcomes in myocardial infarction patients undergoing percutaneous coronary intervention.

Ching-Hui Sia, Junsuk Ko, Huili Zheng, Andrew Fu-Wah Ho, David Foo, Ling-Li Foo, Patrick Zhan-Yun Lim, Boon Wah Liew, Ping Chai, Tiong-Cheng Yeo and 6 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 33 citations in OpenAlex.

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  8. Impact of health awareness on myocardial infarction.The Journal of the Egyptian Public Health Association · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 10 institutions in 3 countries.

Ching-Hui Sia *Department of Cardiology, National University Heart Centre Singapore, Singapore, Singapore.
Junsuk Ko *MD Program, Duke-NUS Medical School, Singapore, Singapore.
Huili ZhengHealth Promotion Board, National Registry of Diseases Office, Singapore, Singapore.
Andrew Fu-Wah HoSingHealth Duke-NUS Emergency Medicine Academic Clinical Programme, Singapore, Singapore.
David FooTan Tock Seng Hospital, Singapore, Singapore.
Ling-Li FooHealth Promotion Board, National Registry of Diseases Office, Singapore, Singapore.
Patrick Zhan-Yun LimKhoo Teck Puat Hospital, Singapore, Singapore.
Boon Wah LiewChangi General Hospital, Singapore, Singapore.
Ping ChaiDepartment of Cardiology, National University Heart Centre Singapore, Singapore, Singapore.
Tiong-Cheng YeoDepartment of Cardiology, National University Heart Centre Singapore, Singapore, Singapore.
Huay-Cheem TanDepartment of Cardiology, National University Heart Centre Singapore, Singapore, Singapore.
Terrance ChuaDepartment of Cardiology, National Heart Centre Singapore, Singapore, Singapore.
Mark Yan-Yee ChanDepartment of Cardiology, National University Heart Centre Singapore, Singapore, Singapore.
Jack Wei Chieh TanDepartment of Cardiology, National Heart Centre Singapore, Singapore, Singapore.
Heerajnarain BulluckNorfolk and Norwich University Hospital, Norwich, UK.
Derek J HausenloyYong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. derek.hausenloy@duke-nus.edu.sg.
National University of Singapore · SGDuke-NUS Medical School · SGHealth Promotion Board · SGNational Heart Centre Singapore · SGNational University Heart Centre Singapore · SGAsia University · TWChangi General Hospital · SGKhoo Teck Puat Hospital · SGTan Tock Seng Hospital · SGUniversity of East Anglia · GB

Funding

British Heart Foundation CS/14/3/31002
6 · The paper itself

Abstract

Smoking is one of the leading risk factors for cardiovascular diseases, including ischemic heart disease and hypertension. However, in acute myocardial infarction (AMI) patients, smoking has been associated with better clinical outcomes, a phenomenon termed the "smoker's paradox." Given the known detrimental effects of smoking on the cardiovascular system, it has been proposed that the beneficial effect of smoking on outcomes is due to age differences between smokers and non-smokers and is therefore a smoker's pseudoparadox. The aim of this study was to evaluate the association between smoking status and clinical outcomes in ST-segment elevation (STEMI) and non-STEMI (NSTEMI) patients treated by percutaneous coronary intervention (PCI), using a national multi-ethnic Asian registry. In unadjusted analyses, current smokers had better clinical outcomes following STEMI and NSTEMI. However, after adjusting for age, the protective effect of smoking was lost, confirming a smoker's pseudoparadox. Interestingly, although current smokers had increased risk for recurrent MI within 1 year after PCI in both STEMI and NSTEMI patients, there was no increase in mortality. In summary, we confirm the existence of a smoker's pseudoparadox in a multi-ethnic Asian cohort of STEMI and NSTEMI patients and report increased risk of recurrent MI, but not mortality, in smokers.

Indexed as

AgedFemaleHumansMaleMiddle AgedNon-ST Elevated Myocardial InfarctionPercutaneous Coronary InterventionPostoperative ComplicationsST Elevation Myocardial InfarctionTobacco SmokingTreatment Outcome

Identifiers

PMID33742073
PMCPMC7979717
OpenAlexW3137025699

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.