Evidence map›Paper›PMID 33742042›Full record

ArticleScientific reports2021

Terahertz refractive index-based morphological dilation for breast carcinoma delineation.

Quentin Cassar, Samuel Caravera, Gaëtan MacGrogan, Thomas Bücher, Philipp Hillger, Ullrich Pfeiffer, Thomas Zimmer, Jean-Paul Guillet, Patrick Mounaix

Abstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Biomedical application of terahertz imaging technology: a narrative review.Quantitative imaging in medicine and surgery · 2023
    Review
  4. Triage ofBiomedical optics express · 2023
    Article
  5. Article
  6. Article
  7. Terahertz Imaging for Breast Cancer Detection.Sensors (Basel, Switzerland) · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Quentin CassarIntegration from Material to Systems Laboratory, University of Bordeaux, 33405, Talence, France.
Samuel CaraveraDepartment of Pathology, Bergonié Institute, 33076, Bordeaux, France.
Gaëtan MacGroganDepartment of Pathology, Bergonié Institute, 33076, Bordeaux, France.
Thomas BücherInstitute for High-Frequency and Communication Technology, University of Wuppertal, 42119, Wuppertal, Germany.
Philipp HillgerInstitute for High-Frequency and Communication Technology, University of Wuppertal, 42119, Wuppertal, Germany.
Ullrich PfeifferInstitute for High-Frequency and Communication Technology, University of Wuppertal, 42119, Wuppertal, Germany.
Thomas ZimmerIntegration from Material to Systems Laboratory, University of Bordeaux, 33405, Talence, France.
Jean-Paul GuilletIntegration from Material to Systems Laboratory, University of Bordeaux, 33405, Talence, France.
Patrick MounaixIntegration from Material to Systems Laboratory, University of Bordeaux, 33405, Talence, France. patrick.mounaix@u-bordeaux.fr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This paper reports investigations led on the combination of the refractive index and morphological dilation to enhance performances towards breast tumour margin delineation during conserving surgeries. The refractive index map of invasive ductal and lobular carcinomas were constructed from an inverse electromagnetic problem. Morphological dilation combined with refractive index thresholding was conducted to classify the tissue regions as malignant or benign. A histology routine was conducted to evaluate the performances of various dilation geometries associated with different thresholds. It was found that the combination of a wide structuring element and high refractive index was improving the correctness of tissue classification in comparison to other configurations or without dilation. The method reports a sensitivity of around 80% and a specificity of 82% for the best case. These results indicate that combining the fundamental optical properties of tissues denoted by their refractive index with morphological dilation may open routes to define supporting procedures during breast-conserving surgeries.

Indexed as

Margins of ExcisionBreast NeoplasmsCarcinomaDiagnostic ImagingFemaleHumansImage Processing, Computer-AssistedRefractometrySpectrum Analysis

Identifiers

PMID33742042
PMCPMC7979939

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.