Evidence map›Paper›PMID 33741997›Full record

ArticleNPJ genomic medicine2021

Unmapped exome reads implicate a role for Anelloviridae in childhood HIV-1 long-term non-progression.

Savannah Mwesigwa, Lesedi Williams, Gaone Retshabile, Eric Katagirya, Gerald Mboowa, Busisiwe Mlotshwa, Samuel Kyobe, David P Kateete, Eddie Mujjwiga Wampande, Misaki Wayengera and 18 more

Open access · goldAbstract read
In one paragraph

Article in NPJ genomic medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Intracranial infection caused byThe Journal of international medical research · 2025
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors at 8 institutions in 5 countries.

Savannah MwesigwaCollege of Health Sciences, Makerere University, Kampala, Uganda.ORCID http://orcid.org/0000-0001-5466-2315
Lesedi WilliamsUniversity of Botswana, Gaborone, Botswana.
Gaone RetshabileUniversity of Botswana, Gaborone, Botswana.ORCID http://orcid.org/0000-0003-1721-0963
Eric KatagiryaCollege of Health Sciences, Makerere University, Kampala, Uganda.
Gerald MboowaCollege of Health Sciences, Makerere University, Kampala, Uganda.
Busisiwe MlotshwaUniversity of Botswana, Gaborone, Botswana.
Samuel KyobeCollege of Health Sciences, Makerere University, Kampala, Uganda.ORCID http://orcid.org/0000-0003-0444-5608
David P KateeteCollege of Health Sciences, Makerere University, Kampala, Uganda.
Eddie Mujjwiga WampandeCollege of Health Sciences, Makerere University, Kampala, Uganda.ORCID http://orcid.org/0000-0003-0012-8883
Misaki WayengeraCollege of Health Sciences, Makerere University, Kampala, Uganda.
Sununguko Wata MpolokaUniversity of Botswana, Gaborone, Botswana.
Angella N MirembeBaylor College of Medicine Children's Foundation Uganda (Baylor Uganda), Kampala, Uganda.
Ishmael KasvosveUniversity of Botswana, Gaborone, Botswana.
Koketso MorapediUniversity of Botswana, Gaborone, Botswana.ORCID http://orcid.org/0000-0001-5439-7080
Grace P KisituBaylor College of Medicine Children's Foundation Uganda (Baylor Uganda), Kampala, Uganda.
Adeodata R KekitiinwaBaylor College of Medicine Children's Foundation Uganda (Baylor Uganda), Kampala, Uganda.
Gabriel AnabwaniBotswana-Baylor Children's Clinical Centre of Excellence, Gaborone, Botswana.
Moses L JolobaCollege of Health Sciences, Makerere University, Kampala, Uganda.
Enock MatovuCollege of Veterinary Medicine, Animal Resources and Biosecurity, Makerere University, Kampala, Uganda.
Julius MulindwaCollege of Veterinary Medicine, Animal Resources and Biosecurity, Makerere University, Kampala, Uganda.
Harry NoyesInstitute of Integrative Biology, University of Liverpool, Liverpool, UK.
Gerrit BothaInstitute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.
Collaborative African Genomics Network (CAfGEN)
TrypanoGEN Research Group
Chester W BrownUniversity of Tennessee Health Science Center, Le Bonheur Children's Hospital, Memphis, TN, USA.
Graeme MardonDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.
Mogomotsi MatshabaBotswana-Baylor Children's Clinical Centre of Excellence, Gaborone, Botswana.
Neil A HanchardDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA. hanchard@bcm.edu.ORCID http://orcid.org/0000-0003-1925-2665
Makerere University · UGUniversity of Botswana · BWBaylor College of Medicine · USBaylor College of Medicine Children’s Foundation · UGBotswana-Baylor Children's Clinical Center of Excellence · BWUniversity of Tennessee Health Science Center · USUniversity of Cape Town · ZAUniversity of Liverpool · GB

Funding

Phenotyping and BioarchivingU54AI110398 · NIAID · BOTSWANA BAYLOR CHILD/CLINCAL CTR/EXCELL · PI MATSHABA, MOGOMOTSI SANDY · 2014 to 2021
$8.9M
Multi-omics Studies of Childhood Complex Traits in Diverse PopulationsZIAHG200412 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI HANCHARD, NEIL · 2021 to 2025
$8.2M
NIAID NIH HHS U54 AI110398United States Department of Agriculture | Agricultural Research Service (USDA Agricultural Research Service) 3092-51000-057-04SU.S. Department of Health & Human Services | NIH | National Human Genome Research Institute (NHGRI) 54AI110398U.S. Department of Health & Human Services | NIH | National Human Genome Research Institute (NHGRI) U54AI110398Wellcome TrustWellcome Trust (Wellcome) H3A/18/004
6 · The paper itself

Abstract

Human immunodeficiency virus (HIV) infection remains a significant public health burden globally. The role of viral co-infection in the rate of progression of HIV infection has been suggested but not empirically tested, particularly among children. We extracted and classified 42 viral species from whole-exome sequencing (WES) data of 813 HIV-infected children in Botswana and Uganda categorised as either long-term non-progressors (LTNPs) or rapid progressors (RPs). The Ugandan participants had a higher viral community diversity index compared to Batswana (p = 4.6 × 10

Identifiers

PMID33741997
PMCPMC7979878
OpenAlexW3136633095

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.