Evidence map›Paper›PMID 33741971›Full record

ArticleNature communications2021

Dietary restriction transforms the mammalian protein persulfidome in a tissue-specific and cystathionine γ-lyase-dependent manner.

Nazmin Bithi, Christopher Link, Yoko O Henderson, Suzie Kim, Jie Yang, Ling Li, Rui Wang, Belinda Willard, Christopher Hine

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 1 pooled it
5.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.

  1. Recent Advances in Molecular Research on Hydrogen Sulfide (HInternational journal of molecular sciences · 2022
    Pooled it
  2. Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. Changes in the brain [NADFrontiers in aging neuroscience · 2026
    Review
  8. Cystathionine γ-lyase is a major regulator of cognitive function through neurotrophin signaling and neurogenesis.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  9. Article
  10. Review
  11. Targeting macro- and micro-nutrient regulation of HNeurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025
    Review
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Nazmin BithiDepartment of Cardiovascular and Metabolic Sciences, Cleveland Clinic Lerner Research Institute, Cleveland, OH, USA.
Christopher LinkDepartment of Cardiovascular and Metabolic Sciences, Cleveland Clinic Lerner Research Institute, Cleveland, OH, USA.
Yoko O HendersonDepartment of Cardiovascular and Metabolic Sciences, Cleveland Clinic Lerner Research Institute, Cleveland, OH, USA.
Suzie KimDepartment of Cardiovascular and Metabolic Sciences, Cleveland Clinic Lerner Research Institute, Cleveland, OH, USA.
Jie YangDepartment of Cardiovascular and Metabolic Sciences, Cleveland Clinic Lerner Research Institute, Cleveland, OH, USA.
Ling LiProteomics and Metabolomics Core Laboratory, Cleveland Clinic Lerner Research Institute, Cleveland, OH, USA.
Rui WangDepartment of Biology, Faculty of Science, York University, Toronto, ON, Canada.
Belinda WillardProteomics and Metabolomics Core Laboratory, Cleveland Clinic Lerner Research Institute, Cleveland, OH, USA.
Christopher HineDepartment of Cardiovascular and Metabolic Sciences, Cleveland Clinic Lerner Research Institute, Cleveland, OH, USA. hinec@ccf.org.ORCID 0000-0003-1926-7939
Cleveland Clinic Lerner College of Medicine · USYork University · CA

Funding

Iron Catalyzed H2S and its Prevalence in Hemolytic and Iron Overload DisordersR01HL148352 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI HINE, CHRISTOPHER MICHAEL · 2019 to 2021
$964k
High-End Instrumentation (HEI) Grant Program (S10)S10OD023436 · OD · CLEVELAND CLINIC LERNER COM-CWRU · PI WILLARD, BELINDA BELLE · 2017 to 2017
$873k
Requirement of hydrogen sulfide for the benefits of dietary sulfur amino acid restrictionR00AG050777 · NIA · CLEVELAND CLINIC LERNER COM-CWRU · PI HINE, CHRISTOPHER MICHAEL · 2017 to 2019
$747k
NHLBI NIH HHS R01 HL148352NIA NIH HHS R00 AG050777NIH HHS S10 OD023436
6 · The paper itself

Abstract

Hydrogen sulfide (H

Indexed as

DietAgingAnimalsBrainCystathionine gamma-LyaseHydrogen SulfideKidneyLiverLongevityMaleMiceMice, Inbred C57BLMice, KnockoutMusclesProteinsTranscriptomeCystathionine gamma-LyaseHydrogen SulfideProteins

Identifiers

PMID33741971
PMCPMC7979915
OpenAlexW3137838596

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.