Evidence map›Paper›PMID 33741963›Full record

ArticleNature communications2021

Molecular basis of V-ATPase inhibition by bafilomycin A1.

Rong Wang, Jin Wang, Abdirahman Hassan, Chia-Hsueh Lee, Xiao-Song Xie, Xiaochun Li

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 107 papers.

0numbers the graph read from it
0cells of the map it votes in
107citing papers in PubMed
10.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

107 citing papers in PubMed, 196 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. TPC1-dependent control of endosomal pH and transferrin uptake determines cellular iron status.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. A cytokine receptor-targeting chimera toolbox for expanding extracellular targeted protein degradation.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  19. Article
  20. The V-ATPase VJournal of oral microbiology · 2026
    Article

47 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Rong WangDepartment of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0001-7342-5278
Jin WangEugene McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Abdirahman HassanDepartment of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Chia-Hsueh LeeDepartment of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID 0000-0003-0819-6477
Xiao-Song XieEugene McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, TX, USA. xiao-song.xie@utsouthwestern.edu.ORCID 0000-0001-7013-4571
Xiaochun LiDepartment of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX, USA. xiaochun.li@utsouthwestern.edu.ORCID 0000-0002-0177-0803
Southwestern Medical Center · USThe University of Texas Southwestern Medical Center · USSt. Jude Children's Research Hospital · US

Funding

TRANSCRIPTIONAL REGULATION OF LDL RECEPTOR PROMOTERP01HL020948 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI GOLDSTEIN, JOSEPH L · 1985 to 2021
$103.1M
Role of ABCG5 and ABCG8 in Sterol MetabolismR01HL072304 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI HOBBS, HELEN HASKELL · 2003 to 2025
$7.0M
Structural and Functional investigations of Hedgehog Signaling TransductionR01GM135343 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI LI, XIAOCHUN · 2019 to 2022
$1.2M
NHLBI NIH HHS P01 HL020948NHLBI NIH HHS R01 HL072304NIGMS NIH HHS R01 GM135343
6 · The paper itself

Abstract

Pharmacological inhibition of vacuolar-type H

Indexed as

Amino Acid SequenceAnimalsBinding SitesBiocatalysisCattleCryoelectron MicroscopyEnzyme InhibitorsMacrolidesModels, MolecularMolecular StructureProtein BindingProtein DomainsSequence Homology, Amino AcidVacuolar Proton-Translocating ATPasesbafilomycin A1Enzyme InhibitorsMacrolidesVacuolar Proton-Translocating ATPases

Identifiers

PMID33741963
PMCPMC7979754
OpenAlexW3136433059

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.