Evidence map›Paper›PMID 33741956›Full record

ArticleNature communications2021

Prediction of stimulus-independent and task-unrelated thought from functional brain networks.

Aaron Kucyi, Michael Esterman, James Capella, Allison Green, Mai Uchida, Joseph Biederman, John D E Gabrieli, Eve M Valera, Susan Whitfield-Gabrieli

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed, 2 pooled it
9.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 2 syntheses or guidelines pooled it, 96 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Real-time fMRI-triggered experience-sampling: a proof-of-concept study.bioRxiv : the preprint server for biology · 2026
    Article
  6. Neurochemical Correlates of Mind-Wandering and Meta-Awareness.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
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  10. Distinct timescales dissociate spontaneous thought dimensions.Proceedings of the National Academy of Sciences of the United States of America · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 1 country.

Aaron KucyiDepartment of Psychology, Northeastern University, Boston, MA, USA. a.kucyi@northeastern.edu.ORCID 0000-0001-6707-0028
Michael EstermanNational Center for PTSD & Neuroimaging Research for Veterans Center (NeRVe), Veterans Administration Boston Healthcare System, Boston, MA, USA.
James CapellaDepartment of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.
Allison GreenClinical and Research Program in Pediatric Psychopharmacology and Adult ADHD, Massachusetts General Hospital, Boston, MA, USA.
Mai UchidaClinical and Research Program in Pediatric Psychopharmacology and Adult ADHD, Massachusetts General Hospital, Boston, MA, USA.
Joseph BiedermanClinical and Research Program in Pediatric Psychopharmacology and Adult ADHD, Massachusetts General Hospital, Boston, MA, USA.
John D E GabrieliDepartment of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.
Eve M Valera *Department of Psychiatry, Harvard Medical School, Boston, MA, USA.
Susan Whitfield-Gabrieli *Department of Psychology, Northeastern University, Boston, MA, USA.
Harvard University · USNortheastern University · USBoston University · USInstitute of Cognitive and Brain Sciences · USMassachusetts General Hospital · USMcGovern Institute for Brain Research · US

Funding

ULTRAHIGH FIELD TECHNOLOGY FOR FUNCTIONAL IMAGINGP41RR014075 · NCRR · MASSACHUSETTS GENERAL HOSPITAL · PI WALD, LAWRENCE L · 1999 to 2011
$16.4M
Project 4P41EB015896 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI ROSEN, BRUCE R · 2012 to 2018
$9.8M
The role of corticocerebellar pathophysiology in adult ADHDR01HD067744 · NICHD · MASSACHUSETTS GENERAL HOSPITAL · PI VALERA, EVE M · 2011 to 2015
$2.6M
Neural and Clinical Biomarkers of Risk for ADHD: A Focus on PreschoolersK23MH122667 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI UCHIDA, MAI · 2020 to 2024
$998k
NCRR NIH HHS P41 RR014075NIBIB NIH HHS P41 EB015896NICHD NIH HHS R01 HD067744NIMH NIH HHS K23 MH122667
6 · The paper itself

Abstract

Neural substrates of "mind wandering" have been widely reported, yet experiments have varied in their contexts and their definitions of this psychological phenomenon, limiting generalizability. We aimed to develop and test the generalizability, specificity, and clinical relevance of a functional brain network-based marker for a well-defined feature of mind wandering-stimulus-independent, task-unrelated thought (SITUT). Combining functional MRI (fMRI) with online experience sampling in healthy adults, we defined a connectome-wide model of inter-regional coupling-dominated by default-frontoparietal control subnetwork interactions-that predicted trial-by-trial SITUT fluctuations within novel individuals. Model predictions generalized in an independent sample of adults with attention-deficit/hyperactivity disorder (ADHD). In three additional resting-state fMRI studies (total n = 1115), including healthy individuals and individuals with ADHD, we demonstrated further prediction of SITUT (at modest effect sizes) defined using multiple trait-level and in-scanner measures. Our findings suggest that SITUT is represented within a common pattern of brain network interactions across time scales and contexts.

Indexed as

AdolescentAdultAttention Deficit Disorder with HyperactivityBrainCohort StudiesConnectomeFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedNerve NetNeural PathwaysNeuropsychological TestsRestYoung Adult

Identifiers

PMID33741956
PMCPMC7979817
OpenAlexW3137188864

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.