Evidence map›Paper›PMID 33741932›Full record

ArticleNature communications2021

Multiplexed histology analyses for the phenotypic and spatial characterization of human innate lymphoid cells.

Anna Pascual-Reguant, Ralf Köhler, Ronja Mothes, Sandy Bauherr, Daniela C Hernández, Ralf Uecker, Karolin Holzwarth, Katja Kotsch, Maximilian Seidl, Lars Philipsen and 4 more

Abstract read
In one paragraph

Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Regulation of innate lymphoid cell by microbial metabolites.Journal of molecular medicine (Berlin, Germany) · 2025
    Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Spatial transcriptomics andFrontiers in immunology · 2024
    Article
  16. Article
  17. Article
  18. Article
  19. ILC3: a case of conflicted identity.Frontiers in immunology · 2023
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Anna Pascual-ReguantCharité - Universitätsmedizin Berlin, Department of Rheumatology and Clinical Immunology, 10117, Berlin, Germany.ORCID 0000-0002-5042-3699
Ralf KöhlerImmune Dynamics, Deutsches Rheuma-Forschungszentrum (DRFZ), a Leibniz Institute, Charitéplatz 1, 10117, Berlin, Germany.
Ronja MothesCharité - Universitätsmedizin Berlin, Department of Rheumatology and Clinical Immunology, 10117, Berlin, Germany.
Sandy BauherrImmune Dynamics, Deutsches Rheuma-Forschungszentrum (DRFZ), a Leibniz Institute, Charitéplatz 1, 10117, Berlin, Germany.ORCID 0000-0002-3736-3361
Daniela C HernándezInnate Immunity, Deutsches Rheuma-Forschungszentrum (DRFZ), a Leibniz Institute, Berlin, Germany.ORCID 0000-0001-5960-160X
Ralf UeckerCharité - Universitätsmedizin Berlin, Department of Rheumatology and Clinical Immunology, 10117, Berlin, Germany.
Karolin HolzwarthImmune Dynamics, Deutsches Rheuma-Forschungszentrum (DRFZ), a Leibniz Institute, Charitéplatz 1, 10117, Berlin, Germany.
Katja KotschCharité - Universitätsmedizin Berlin, Department for General, Visceral and Vascular Surgery, Berlin, Germany.
Maximilian SeidlInstitute for Surgical Pathology, Medical Center-University of Freiburg, Freiburg, Germany.ORCID 0000-0002-5559-4980
Lars PhilipsenInstitute of Molecular and Clinical Immunology, Medical Center, Otto-von-Guericke University Magdeburg, Magdeburg, Germany.ORCID 0000-0001-5112-495X
Werner MüllerMiltenyi Biotec B.V. & Co. KG, Bergisch Gladbach, Germany.
Chiara RomagnaniInnate Immunity, Deutsches Rheuma-Forschungszentrum (DRFZ), a Leibniz Institute, Berlin, Germany.ORCID 0000-0002-5167-7463
Raluca NiesnerBiophysical Analysis, Deutsches Rheuma-Forschungszentrum (DRFZ), a Leibniz Institute, Berlin, Germany.ORCID 0000-0001-8969-5432
Anja E HauserCharité - Universitätsmedizin Berlin, Department of Rheumatology and Clinical Immunology, 10117, Berlin, Germany. anja.hauser-hankeln@charite.de.ORCID 0000-0002-7725-9526

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Innate lymphoid cells (ILCs) emerge in the last few years as important regulators of immune responses and biological processes. Although ILCs are mainly known as tissue-resident cells, their precise localization and interactions with the microenvironment are still unclear. Here we combine a multiplexed immunofluorescence technique and a customized computational, open-source analysis pipeline to unambiguously identify CD127

Indexed as

PhenotypeSpatial AnalysisAlgorithmsCluster AnalysisConnective TissueHumansImage Processing, Computer-AssistedImmunity, InnateInterferon Regulatory Factor-4Interferon Regulatory FactorsInterleukin-7 Receptor alpha SubunitLymphocytesMachine LearningPalatine TonsilInterferon Regulatory Factor-4Interferon Regulatory FactorsInterleukin-7 Receptor alpha Subunit

Identifiers

PMID33741932
PMCPMC7979823

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.