Evidence map›Paper›PMID 33741927›Full record

ArticleNature communications2021

Crystal structures of human MGST2 reveal synchronized conformational changes regulating catalysis.

Madhuranayaki Thulasingam, Laura Orellana, Emmanuel Nji, Shabbir Ahmad, Agnes Rinaldo-Matthis, Jesper Z Haeggström

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
8.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 44 citations in OpenAlex.

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  13. Biosynthesis of prostaglandin 15dPGJJournal of lipid research · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Madhuranayaki ThulasingamDepartment of Medical Biochemistry and Biophysics, Division of Chemistry II, Karolinska Institutet, Solnavägen 9, 171 65 Stockholm, Sweden. madhuranayaki.thulasingam@ki.se.ORCID 0000-0002-4277-9839
Laura OrellanaDepartment of Biochemistry and Biophysics, Stockholm University, Svante Arrhenius väg 16, 106 91 Stockholm, Sweden.
Emmanuel NjiDepartment of Biochemistry and Biophysics, Stockholm University, Svante Arrhenius väg 16, 106 91 Stockholm, Sweden.ORCID 0000-0001-6991-1046
Shabbir AhmadDepartment of Medical Biochemistry and Biophysics, Division of Chemistry II, Karolinska Institutet, Solnavägen 9, 171 65 Stockholm, Sweden.ORCID 0000-0003-2374-1197
Agnes Rinaldo-MatthisDepartment of Medical Biochemistry and Biophysics, Division of Chemistry II, Karolinska Institutet, Solnavägen 9, 171 65 Stockholm, Sweden.
Jesper Z HaeggströmDepartment of Medical Biochemistry and Biophysics, Division of Chemistry II, Karolinska Institutet, Solnavägen 9, 171 65 Stockholm, Sweden. Jesper.Haeggstrom@ki.se.
Karolinska Institutet · SEStockholm University · SEUppsala University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Microsomal glutathione S-transferase 2 (MGST2) produces leukotriene C

Indexed as

Binding SitesCatalysisCatalytic DomainCrystallography, X-RayEndoplasmic ReticulumGlutathione TransferaseHumansLeukotriene C4Molecular Dynamics SimulationMutagenesis, Site-DirectedOxidative StressProtein ConformationGlutathione TransferaseLeukotriene C4leukotriene-C4 synthase

Identifiers

PMID33741927
PMCPMC7979937
OpenAlexW3136377147

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.