ArticleNature communications2021
Synchronous RNA conformational changes trigger ordered phase transitions in crystals.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Convergent-beam X-ray crystallography.Journal of applied crystallography · 2026Article
- Advances in microfluidic mixers for time-resolved structural biology with X-rays.Biophysical reviews · 2025Review
- Structural biology in the age of X-ray free-electron lasers and exascale computing.Current opinion in structural biology · 2024Review
- The time revolution in macromolecular crystallography.Structural dynamics (Melville, N.Y.) · 2024Article
- Computational Modeling of RNA Aptamers: Structure Prediction of the Apo State.The journal of physical chemistry. B · 2022Article
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- Developing methods to study conformational changes in RNA crystals using a photocaged ligand.Frontiers in molecular biosciences · 2022Article
- Best practices for time-resolved serial synchrotron crystallography.Acta crystallographica. Section D, Structural biology · 2022Review
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- Article
- Article
- A combined approach to characterize ligand-induced solid-solid phase transitions in biomacromolecular crystals.Journal of applied crystallography · 2021Article
- Dependence of phase transition uniformity on crystal sizes characterized using birefringence.Structural dynamics (Melville, N.Y.) · 2021Article
- Tying the knot in the tetrahydrofolate (THF) riboswitch: A molecular basis for gene regulation.Journal of structural biology · 2021Article
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Authors and funding
30 authors.
Funding
Abstract
Time-resolved studies of biomacromolecular crystals have been limited to systems involving only minute conformational changes within the same lattice. Ligand-induced changes greater than several angstroms, however, are likely to result in solid-solid phase transitions, which require a detailed understanding of the mechanistic interplay between conformational and lattice transitions. Here we report the synchronous behavior of the adenine riboswitch aptamer RNA in crystal during ligand-triggered isothermal phase transitions. Direct visualization using polarized video microscopy and atomic force microscopy shows that the RNA molecules undergo cooperative rearrangements that maintain lattice order, whose cell parameters change distinctly as a function of time. The bulk lattice order throughout the transition is further supported by time-resolved diffraction data from crystals using an X-ray free electron laser. The synchronous molecular rearrangements in crystal provide the physical basis for studying large conformational changes using time-resolved crystallography and micro/nanocrystals.
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