ArticleStroke and vascular neurology2021
Role of depressive symptoms in cardiometabolic diseases and subsequent transitions to all-cause mortality: an application of multistate models in a prospective cohort study.
Article in Stroke and vascular neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- Association between depression and stroke risk in adults: a systematic review and meta-analysis.Frontiers in neurology · 2024Pooled it
- The Effects of Omega-3 Supplementation on Depression in Adults with Cardiometabolic Disease: A Systematic Review of Randomised Control Trials.Nutrients · 2022Pooled it
- A stakeholder-inclusive conceptual framework for modeling routinely collected health data for therapeutic decision-making illustrated by means of multistate models.BMC medical research methodology · 2026Article
- Association between depression and cardiometabolic multimorbidity: A protocol for a systematic review and meta-analysis.PloS one · 2026Article
- Exploring the Joint Impact of METS-VF and Functional Limitation on Cardiometabolic Multimorbidity Risk.Journal of diabetes research · 2026Article
- Cross-sectional associations of metabolic risk indices and cardiometabolic multimorbidity among adults with depressive symptoms: evidence from China and the United Kingdom.Archives of medical science : AMS · 2026Article
- Associations between depression and risk of cardiometabolic multimorbidity among middle-aged and older Chinese adults.Scientific reports · 2025Article
- Different Metabolic Phenotypes of Obesity and 2 Decades Risk of Cardio-Renal-Metabolic Multimorbidity: Tehran Lipid and Glucose Study.Journal of the American Heart Association · 2025Article
- Experience of financial hardship and depression: a longitudinal population-based multi-state analysis.Epidemiology and psychiatric sciences · 2025Article
- The longitudinal association between multiple cardiometabolic diseases, socioeconomic status, and depressive symptoms in China.Scientific reports · 2025Article
- Cardiovascular Disease, Depressive Symptoms, and Heart Failure in Mexican American Aged 75 Years and Older During 12 Years of Follow Up.Journal of affective disorders reports · 2024Article
- Food Insecurity and Diet Quality Among Adults on Medicaid With and Without a Mental Illness Diagnosis.Journal of the Academy of Nutrition and Dietetics · 2023Article
- Exposure to psychotropic medications and mortality in schizophrenia: a 5-year national cohort study.Psychological medicine · 2023Article
- PHQ-9, CES-D, health insurance data-who is identified with depression? A Population-based study in persons with diabetes.Diabetology & metabolic syndrome · 2023Article
- Major depression, physical health and molecular senescence markers abnormalities.Nature. Mental health · 2023Article
- Increases in Prevalent Depressed Mood and Suicidal Ideation among Workers during the COVID-19 Pandemic-Findings from the California Health Interview Survey.International journal of environmental research and public health · 2023Article
- Analysis of Prognostic Risk Factors for Ischemic Stroke in China: A Multicentre Retrospective Clinical Study; A National Survey in China.Current neurovascular research · 2022Article
- Role of handgrip strength in predicting new-onset diabetes: findings from the survey of health, ageing and retirement in Europe.BMC geriatrics · 2021Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
background and purposeThe role of depression in the development and outcome of cardiometabolic diseases remains to be clarified. We aimed to examine the extent to which depressive symptoms affect the transitions from healthy to diabetes, stroke, heart disease and subsequent all-cause mortality in a middle-aged and elderly European population.
methodsA total of 78 212 individuals aged ≥50 years from the Survey of Health Ageing and Retirement in Europe were included. Participants with any baseline cardiometabolic diseases including diabetes, stroke and heart disease were excluded. Depressive symptoms were measured by the Euro-Depression scale at baseline. Participants were followed up to determine the occurrence of cardiometabolic diseases and all-cause mortality. We used multistate models to estimate the transition-specific HRs and 95% CIs after adjustment of confounders.
resultsDuring 500 711 person-years of follow-up, 4742 participants developed diabetes, 2173 had stroke, 5487 developed heart disease and 7182 died. Depressive symptoms were significantly associated with transitions from healthy to diabetes (HR: 1.12, 95% CI: 1.05 to 1.20), stroke (HR: 1.31, 95% CI: 1.18 to 1.44), heart disease (HR: 1.26, 95% CI: 1.18 to 1.34) and all-cause mortality (HR: 1.41, 95% CI: 1.34 to 1.49). After cardiometabolic diseases, depressive symptoms were associated with the increased risk of all-cause mortality in patients with diabetes (HR: 1.54, 95% CI: 1.25 to 1.89), patients who had stroke (HR: 1.29, 95% CI: 1.03 to 1.61) and patients with heart disease (HR: 1.21, 95% CI: 1.02 to 1.44).
conclusionsDepressive symptoms increase the risk of diabetes, stroke and heart disease, and affect the risk of mortality after the onset of these cardiometabolic conditions. Screening and treatment of depressive symptoms may have profound implications for the prevention and prognosis of cardiometabolic diseases.
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