ArticleBMJ open2021
Multimorbidity, ageing and mortality: normative data and cohort study in an American population.
Article in BMJ open, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed.
- Multitissue, multi-time point transcriptomic atlas of aging in mice and rats.Science advances · 2026Article
- Multimorbidity in Atrial Fibrillation: Impact on Outcomes.Journal of the American Heart Association · 2026Article
- Association of multimorbidity with mortality risk in Chinese senior adults: a population-based cohort study.BMC geriatrics · 2026Article
- Adverse childhood experiences increase the long-term accumulation of morbidity in women.Communications medicine · 2025Article
- Women With a History of Preeclampsia Exhibit Accelerated Aging and Unfavorable Profiles of Senescence Markers.Hypertension (Dallas, Tex. : 1979) · 2024Article
- Older Tissue Age Derived From Abdominal Computed Tomography Biomarkers of Muscle, Fat, and Bone Is Associated With Chronic Conditions and Higher Mortality.Mayo Clinic proceedings · 2024Article
- The Role of Individual-Level Socioeconomic Status on Nursing Home Placement Accounting for Neighborhood Characteristics.Journal of the American Medical Directors Association · 2023Article
- Mayo-PACC: A parsimonious preclinical Alzheimer's disease cognitive composite comprised of public-domain measures to facilitate clinical translation.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023Article
- Article
- Inflammatory biomarkers, multi-morbidity, and biologic aging.The Journal of international medical research · 2022Article
- Association of Depression and Anxiety With the Accumulation of Chronic Conditions.JAMA network open · 2022Article
- Associations between multiple long-term conditions and mortality in diverse ethnic groups.PloS one · 2022Article
- Cardiac rehabilitation for older adults: current evidence and future potential.Expert review of cardiovascular therapy · 2022Article
- Convergence of four measures of multi-morbidity.Journal of multimorbidity and comorbidityArticle
- Multi-morbidity and patient-reported functional limitations: a population-based cohort study.Journal of multimorbidity and comorbidityArticle
- Multimorbidity in patients with atrial fibrillation and community controls: A population-based study.Journal of multimorbidity and comorbidityArticle
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
objectivesTo describe the percentile distribution of multimorbidity across age by sex, race and ethnicity, and to demonstrate the utility of multimorbidity percentiles to predict mortality.
designPopulation-based descriptive study and cohort study.
settingOlmsted County, Minnesota (USA).
participantsWe used the medical records-linkage system of the Rochester Epidemiology Project (REP; http://www.rochesterproject.org) to identify all residents of Olmsted County, Minnesota who reached one or more birthdays between 1 January 2005 and 31 December 2014 (10 years).
methodsFor each person, we obtained the count of chronic conditions (out of 20 conditions) present on each birthday by extracting all of the diagnostic codes received in the 5 years before the index birthday from the electronic indexes of the REP. To compare each person's count to peers of same age, the counts were transformed into percentiles of the total population and displayed graphically across age by sex, race and ethnicity. In addition, quintiles 1, 2, 4 and 5 were compared with quintile 3 (reference) to predict the risk of death at 1 year, 5 years and through end of follow-up using time-to-event analyses. Follow-up was passive using the REP.
resultsWe identified 238 010 persons who experienced a total of 1 458 094 birthdays during the study period (median of 6 birthdays per person; IQR 3-10). The percentiles of multimorbidity across age did not vary noticeably by sex, race or ethnicity. In general, there was an increased risk of mortality at 1 and 5 years for quintiles 4 and 5 of multimorbidity. The risk of mortality for quintile 5 was greater for younger age groups and for women.
conclusionsThe assignment of multimorbidity percentiles to persons in a population may be a simple and intuitive tool to assess relative health status, and to predict short-term mortality, especially in younger persons and in women.
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