Evidence map›Paper›PMID 33741657›Full record

ArticleScience immunology2021

Exploiting albumin as a mucosal vaccine chaperone for robust generation of lung-resident memory T cells.

Kavya Rakhra, Wuhbet Abraham, Chensu Wang, Kelly D Moynihan, Na Li, Nathan Donahue, Alexis D Baldeon, Darrell J Irvine

Open access · greenAbstract read
In one paragraph

Article in Science immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 79 citations in OpenAlex.

  1. Review
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  3. Review
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Nanoparticle-Based Pulmonary Immune Engineering.Annual review of chemical and biomolecular engineering · 2025
    Review
  11. Article
  12. COVID-19 vaccines: Immune correlates and clinical outcomes.Human vaccines & immunotherapeutics · 2024
    Review
  13. Article
  14. Article
  15. Synthetic organic materials for targeting immunotherapies to lymph nodes.Chemistry of materials : a publication of the American Chemical Society · 2024
    Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Kavya RakhraKoch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.ORCID 0000-0003-2371-0470
Wuhbet AbrahamKoch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Chensu WangKoch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.ORCID 0000-0001-6996-149X
Kelly D MoynihanKoch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.ORCID 0000-0001-6200-7863
Na LiKoch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Nathan DonahueKoch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Alexis D BaldeonKoch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Darrell J IrvineKoch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. djirvine@mit.edu.ORCID 0000-0002-8637-1405
Ragon Institute of MGH, MIT and Harvard · USMassachusetts Institute of Technology · USHoward Hughes Medical Institute · US

Funding

Enhancing CAR-T cell activity against solid tumors by vaccine boosting through the chimeric receptorR01CA247632 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI IRVINE, DARRELL J · 2020 to 2024
$1.7M
Lymph node-targeted molecular vaccinesR01EB022433 · NIBIB · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI IRVINE, DARRELL J · 2016 to 2019
$1.4M
Howard Hughes Medical InstituteNCI NIH HHS R01 CA247632NIBIB NIH HHS R01 EB022433
6 · The paper itself

Abstract

Tissue-resident memory T cells (T

Indexed as

Adjuvants, ImmunologicImmunity, MucosalImmunologic MemoryAlbuminsAnimalsBiomarkersHost-Pathogen InteractionsImmunizationImmunophenotypingLungLymphocyte ActivationMemory T CellsMiceMice, KnockoutOrgan SpecificityT-Lymphocyte SubsetsAdjuvants, ImmunologicAlbuminsBiomarkersVaccines

Identifiers

PMID33741657
PMCPMC8279396
OpenAlexW3136397845

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.