Evidence map›Paper›PMID 33741643›Full record

ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2021

Dose-Response and Dose-Toxicity Relationships for Glass

Ahmed A Alsultan, Caren van Roekel, Maarten W Barentsz, Maarten L J Smits, Britt Kunnen, Miriam Koopman, Arthur J A T Braat, Rutger C G Bruijnen, Bart de Keizer, Marnix G E H Lam

Registry-linked trialOpen access · bronzeAbstract read
In one paragraph

Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07406126 (Y90 Radioembolization as Neoadjuvant Therapy for Potentially Resectable Patients With Colorectal Liver Metastases), which is not on this map. Cited by 38 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 1 pooled it
5.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07406126 not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Y90 Radioembolization as Neoadjuvant Therapy for Potentially Resectable Patients With Colorectal Liver Metastases: Immune Markers Evaluation, Impact on Circulating Tumor DNA and Personalized Dosimetry Approach

TypeobservationalSponsorFernando Gómez MuñozRan2026 to 2028Enrolled30ConditionsColorectal Liver Metastases (CRCLM), Unresectable Colorectal Liver MetastasesArmsYttrium-90 Radioembolization with standard systemic therapy
3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.

  1. Pooled it
  2. Holmium-166 radioembolisation dosimetry in HCC.European journal of nuclear medicine and molecular imaging · 2025
    Trial
  3. Radioembolization With Chemotherapy for Colorectal Liver Metastases: A Randomized, Open-Label, International, Multicenter, Phase III Trial.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2021
    Trial
  4. Separation ofMolecular imaging and radionuclide therapy · 2026
    Article
  5. Article
  6. Post-hoc analysis of adverse events during the EPOCH trial: reconsidering dosimetry.European journal of nuclear medicine and molecular imaging · 2026
    Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Hepatobiliary PET with [EJNMMI research · 2025
    Article
  12. Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Observational
  20. PET/CT-Based Absorbed Dose Maps inJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Ahmed A AlsultanDivision of Imaging and Oncology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands a.a.n.alsultan@umcutrecht.nl.
Caren van RoekelDivision of Imaging and Oncology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Maarten W BarentszDivision of Imaging and Oncology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Maarten L J SmitsDivision of Imaging and Oncology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Britt KunnenDivision of Imaging and Oncology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Miriam KoopmanDivision of Imaging and Oncology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Arthur J A T BraatDivision of Imaging and Oncology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Rutger C G BruijnenDivision of Imaging and Oncology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Bart de KeizerDivision of Imaging and Oncology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Marnix G E H LamDivision of Imaging and Oncology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Utrecht University · NLUniversity Medical Center Utrecht · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Radioembolization based on personalized treatment planning requires established dose-response and dose-toxicity relationships. The aim of this study was to investigate dose-response and dose-toxicity relationships in patients with colorectal liver metastases (CRLMs) treated with glass

Indexed as

Colorectal NeoplasmsDose-Response Relationship, RadiationEmbolization, TherapeuticGlassLiver NeoplasmsYttrium RadioisotopesAdultAgedAged, 80 and overFemaleHumansMaleMicrospheresMiddle AgedPositron Emission Tomography Computed TomographyRadiotherapy DosageYttrium-90Yttrium Radioisotopes90Y PETcolorectal liver metastasesdose–response relationshipradioembolizationtotal lesion glycolysis

Identifiers

PMID33741643
PMCPMC8612342
OpenAlexW3136043406

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.