ArticleScience advances2021
Lack of support for Deuterostomia prompts reinterpretation of the first Bilateria.
Article in Science advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed.
- Article
- The anti-neural role of BMP signaling is a consequence of its ancestral function in dorsoventral patterning.PLoS biology · 2026Article
- Patterns of Conservation and Loss of Hox Genes in Xenacoelomorph Lineage Since Divergence From Last Common Bilaterian Ancestor.Genome biology and evolution · 2026Article
- AliFilter: a machine learning approach to alignment filtering.Molecular biology and evolution · 2026Article
- Totipotency and high plasticity in an embryo with an invariant, fate-specifying cleavage program.Current biology : CB · 2026Article
- Patterns and determinants of mitogenomic evolution in Bilateria.Nature communications · 2026Article
- Toward a genomic understanding of the tree of life.Molecular biology and evolution · 2026Article
- Comparative transcriptomics reveal the common anteroposterior molecular blueprint of adult bilaterian guts.PLoS biology · 2026Article
- Article
- Chromatin profiling data indicate regulatory mechanisms for differentiation during development in the acoel Hofstenia miamia.Development (Cambridge, England) · 2025Article
- A Phylogenomic Backbone for Acoelomorpha Inferred From Transcriptomic Data.Systematic biology · 2025Article
- Article
- Hemichordate cis-regulatory genomics and the gene expression dynamics of deuterostomes.Nature ecology & evolution · 2024Article
- Ediacaran origin and Ediacaran-Cambrian diversification of Metazoa.Science advances · 2024Article
- Acoelomorph flatworm monophyly is a long-branch attraction artefact obscuring a clade of Acoela and Xenoturbellida.Proceedings. Biological sciences · 2024Article
- Article
- A wound-induced differentiation trajectory for neurons.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- A long-headed Cambrian soft-bodied vertebrate from the American Great Basin region.Royal Society open science · 2024Article
- Chromosome-level genome assemblies of 2 hemichordates provide new insights into deuterostome origin and chromosome evolution.PLoS biology · 2024Article
- Highly conserved and extremely evolvable: BMP signalling in secondary axis patterning of Cnidaria and Bilateria.Development genes and evolution · 2024Review
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The bilaterally symmetric animals (Bilateria) are considered to comprise two monophyletic groups, Protostomia (Ecdysozoa and the Lophotrochozoa) and Deuterostomia (Chordata and the Xenambulacraria). Recent molecular phylogenetic studies have not consistently supported deuterostome monophyly. Here, we compare support for Protostomia and Deuterostomia using multiple, independent phylogenomic datasets. As expected, Protostomia is always strongly supported, especially by longer and higher-quality genes. Support for Deuterostomia, however, is always equivocal and barely higher than support for paraphyletic alternatives. Conditions that cause tree reconstruction errors-inadequate models, short internal branches, faster evolving genes, and unequal branch lengths-coincide with support for monophyletic deuterostomes. Simulation experiments show that support for Deuterostomia could be explained by systematic error. The branch between bilaterian and deuterostome common ancestors is, at best, very short, supporting the idea that the bilaterian ancestor may have been deuterostome-like. Our findings have important implications for the understanding of early animal evolution.
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