ArticleScience advances2021
Pain induces stable, active microcircuits in the somatosensory cortex that provide a therapeutic target.
Article in Science advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed, 78 citations in OpenAlex.
- Article
- Microglia Display Heterogeneous Initial Responses to Disseminated Tumor Cells.Cancer research · 2026Article
- Frequency- and Layer-Specific Modulation of Cortical Neuronal Activity by Pulsed Electrical Stimulation.MedComm · 2026Article
- Drug-caged drugs enable photocatalytic dual decaging of nitric oxide and anesthetics for antibacterial analgesia.Nature communications · 2026Article
- Human neuronal networks on micro-electrode arrays as a tool to assess genotype-phenotype correlation in CACNA1A-related disorders.Stem cell reports · 2026Article
- Dorsal root ganglion neuromodulation restores accumbal gate to inhibit mechanical allodynia.The journal of headache and pain · 2026Article
- Somatosensory cortical progesterone receptor signaling regulates the episodic to chronic migraine transformation.Neurobiology of disease · 2026Article
- Red-shifted excitation enhances the sensitivity of red genetically encoded CaJournal of biomedical optics · 2025Article
- Remote automated delivery of mechanical stimuli coupled to brain recordings in behaving mice.eLife · 2025Article
- N-type CaNPJ Parkinson's disease · 2025Article
- SERBP1-PCIF1 complex-controlled m6Am modification in glutamatergic neurons of the primary somatosensory cortex is required for neuropathic pain in mice.Nature communications · 2025Article
- The Effect of Pexidartinib on Neuropathic Pain via Influences on Microglia and Neuroinflammation in Mice.Anesthesia and analgesia · 2025Article
- Article
- Decoding the mechanism of proanthocyanidins in central analgesia: redox regulation and KCNK3 blockade.Experimental & molecular medicine · 2025Article
- Intra-somatosensory cortical circuits mediating pain-induced analgesia.Nature communications · 2025Article
- Discussion on the Application of Mindfulness Therapy in the Treatment of Diabetic Peripheral Neuropathy: A Narrative Review.Psychology research and behavior management · 2025Review
- Low-intensity sciatic nerve-stretch injury increases nociception, anxiety-like behaviors, and astrocyte activity in male Wistar rats.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2025Article
- Structural brain characteristics of epilepsy patients with comorbid migraine without aura.Scientific reports · 2024Article
- Aging-associated decrease of PGC-1α promotes pain chronification.Aging cell · 2024Article
- Commentary on "Synchronized activity of sensory neurons initiates cortical synchrony in a model of neuropathic pain".Neural regeneration research · 2024Article
Corrections and comments
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Authors and funding
15 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sustained neuropathic pain from injury or inflammation remains a major burden for society. Rodent pain models have informed some cellular mechanisms increasing neuronal excitability within the spinal cord and primary somatosensory cortex (S1), but how activity patterns within these circuits change during pain remains unclear. We have applied multiphoton in vivo imaging and holographic stimulation to examine single S1 neuron activity patterns and connectivity during sustained pain. Following pain induction, there is an increase in synchronized neuronal activity and connectivity within S1, indicating the formation of pain circuits. Artificially increasing neuronal activity and synchrony using DREADDs reduced pain thresholds. The expression of N-type voltage-dependent Ca
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.